Quality Control of Zhisou Qingguo Pills

ZHANG Jian-wei; WANG Rui-feng; YANG Ai-gang; LI Jun-hong; XING Ya-nan; ZHANG Si-ju

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Quality Control of Zhisou Qingguo Pills

更新时间：2024-09-23

- Quality Control of Zhisou Qingguo Pills
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 9, Pages: 133-136(2012)
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- Published：2012
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ZHANG Jian-wei, WANG Rui-feng, YANG Ai-gang, et al. Quality Control of Zhisou Qingguo Pills[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 133-136.
DOI：

ZHANG Jian-wei, WANG Rui-feng, YANG Ai-gang, et al. Quality Control of Zhisou Qingguo Pills[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 133-136. DOI：

摘要

目的:为了提高止嗽青果丸的质量标准

建立止嗽青果丸质量控制的定性与定量方法。方法:采用薄层色谱法对处方中西青果以甲苯 -乙酸乙酯 -甲酸(5∶4∶1)、麻黄以三氯甲烷 -甲醇 -浓氨水(20∶5∶0.5)为展开剂进行色谱鉴别;采用高效液相色谱法进行定量分析

以乙腈-0.1%磷酸溶液[5∶95(内含0.1%三乙胺)]为流动相

色谱柱kromasil-C18(4.6 mm×250 mm

5 μm)

流速0.8 mL·min-1

检测波长210 nm

柱温35 ℃。结果:薄层色谱图谱中能清晰检出西青果、麻黄;盐酸麻黄碱进样量在0.085~0.427 2 μg线性关系良好(r =0.999 8);平均回收率为95.88%

RSD 1.17%。结论:本方法专属性强

准确、简便

可作为止嗽青果丸的质量控制。

Abstract

Objective: For improving the quality level of Zhisou Qingguo pill

the qualitative and quantitative method for controlling the quality of Zhisou Qingguo pills was established. Method: Thin-layer chromatography was used for identifying the Fructus Terminaliae Immaturus which was developed with toluene-ethyl acetate-formic acid (5∶4∶1)

and ephedra developed with chloroform-methanol-strong ammonia (20∶5∶0.5); HPLC method was used for quantitative analysis with Acetonitrile-0.1% phosphoric acid solution [5∶95(containing 0.1% triethylamine)] as mobile phase

the flow rate was 0.8 mL·min-1 flow rate

detection wavelength was at 210 nm and column temperature was at 350 ℃. Result: Fructus Terminaliae Immaturus and ephedra were clearly detected in Thin-layer chromatography atlas; Linear relationship was set up (r =0.999 8) within 0.085-0.427 2 μg as the sample size of Ephedrine hydrochloride; The average recovery was 95.88%; RSD was 1.17%. Conclusion: The method was exclusive

accurate

and simple

and it can be used for the quality control of Zhisou Qingguo pills.

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Related Author

ZHANG Jian-wei1

WANG Rui-feng1

YANG Ai-gang1

LI Jun-hong1

XING Ya-nan1

ZHANG Si-ju2

HAO Yadong

MA Kun

Related Institution

Level 3 Laboratory for State Administration of Traditional Chinese Medicine,Beijing Zhendong Guangming Pharmaceutical Research Institute Co.,Ltd

Institute of Chinese Meteria Medica,China Academy of Chinese Medical Sciences

Haidian District Food and Drug Safety Monitoring Center

China Academy of Chinese Medical Sciences

College of Pharmacy， Shaanxi University of Chinese Medicine

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