Imaging System in Detecting Distribution of Liposomes Modified with Glycyrrhetinic Acid
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Imaging System in Detecting Distribution of Liposomes Modified with Glycyrrhetinic Acid
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 17, Pages: 148-152(2012)
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Published:2012
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CHEN Zhi-peng, XIAO Lu, LI Wei-dong, et al. Imaging System in Detecting Distribution of Liposomes Modified with Glycyrrhetinic Acid[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 148-152.
DOI:
CHEN Zhi-peng, XIAO Lu, LI Wei-dong, et al. Imaging System in Detecting Distribution of Liposomes Modified with Glycyrrhetinic Acid[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 148-152.DOI:
Imaging System in Detecting Distribution of Liposomes Modified with Glycyrrhetinic Acid
Objective: To prove the long-circulating and distribution of liposome which is modified with choesterol-poly (ethylene glycol)2000-glycyrrhetinic acid (Chol-PEG-GA)(CPGL) in vivo and provide theoretical basis for targeting therapy of tumor. Method: The biodistribution of NIRD-15 labeled liposome was studied in mice by fluorescence animal imaging. The mice were randomly separated in conventional liposomes (LP) group and CPGL group. The fluorescence intensities in vivo and in isolated organs were measured 5
10
15
30
60
120
180
360
600 min after injection. Result: LP faded away quickly through metabolism in organs of body
transferred by circulation system
while few phenomenon of NIRD-15's enrichment in liver occurred. After injected CPGL into body
the content ratio of NIRD-15 in the body was increased slowly. The phenomenon of NIRD-15 enrichment occurred in the liver 15 min after administration
and the concentration was still higher than LP after 600 min
which suggested liposomes modified with Chol-PEG-GA can target to the liver and extend its residence time in liver. Conclusion: CPGL can control the release of the drug in vivo
Preparation and in vivo Distribution of Essential Oil from Alpinia zerumbet Fructus Encapsulated Nanoemulsions
Determination of Content and Entrapment Efficiency of Vinorelbine Encapsulated in Liposomes
Study on Separation of Passive Absorption Active Constituents of Aqueous Extract of Traditional Chinese Medicine by Liposome Liquid Membrane Extraction Technology
Preparation and Safety Evaluation of Vinorelbine Liposems
Preparation and its release in vitro of Vinorelbine encapsulated in liposomes
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