Objective: To observe the effect of Shenxiong Huayu capsule on infracted volume

contents of brain water and the changes of morphological and ultrastructure of acute cerebral ischemia reperfusion in ratsand investigate the protective effect of Shenxiong Huayu capsule on acute cerebral ischemia reperfusion injury in rats. Method: The rats were randomly divided into five groups: sham operation group

ischemia reperfusion group (model group)

Shenxiong Huayu capsule high

medium and low dose group(480

240

120 mg·kg-1). Intragastric administration lasted 7 day

once a day. Middle cerebral artery occlusion (MCAO) and reperfushion model was made by an intraluminal filament method. The infracted volume was measured by TTC staining

contents of brain water was measured by dry-wet method and the morphological changes were observed using light and election microscope. Result: Compared with the sham operation group

the infracted volume and contents of brain water were increased in model group and showed a significant difference(all P<0.05); compared with the model group

the infracted volume and contents of brain water were reduced in Shenxiong Huayu capsule dose groups

showed a significant difference(P<0.05

or P<0.01)

the high dose group showed most significant actions. Under the light and election microscope

the changes of morphological and ultrastructure of changes were reduced in Shenxiong Huayu capsule groups

and the high dose group showed most significant actions. Conclusion: Shenxiong Huayu capsule may relive acute cerebral ischemia reperfusion injury in rats.