Objective : To observe the impact of bufei capsule on chronic obstructive pulmonary disease (COPD) in rats model. Method : The model of COPD was established by applying intra-tracheal injection of lipopdysaccharide(LPS) and smoking. The drugs was given by gavages for four weeks

and the changes of lung function was observed. The ear swelling method and the carbon clearance test

ammonia cited cough

histamine induced asthma method and phenol red method were used to observe the anti-inflammatory

immunity regulation and relieving cough

asthma and phlegm. Result : Compared with the model group

the indexes of forced expiratory volume in 0.3 seeond(FEV0.3)

forced vital capaeity(FVC)

FEV0.3/FVC and arterial pH

partial pressure of oxygen(PaO2) increased (P<0.01 or P<0.05)

and carbon dioxide partial pressure(PaCO2) decreased (P<0.01 or P<0.05) in the bufei capsule group.The relieving cough

asthma and phlegm anti-inflammatory effects and immunoregulation were more significant in bufei casule group than that in modle group. (P<0.01 or P<0.05). Conclusion : The Bufei capsule can improve lung function and a variety of clinical manifestations in COPD.