Objective: To optimize extraction and purification technology of total flavones from Aster ageratoides. Method: With the content of total flavones as index

extraction technology conditions of total flavones was optimized by orthogonal test;Type of macroporous resin was selected with static adsorption capacity and desorption rate as indexes

and to optimized purification technology of total flavones. Result: Optimum extraction conditions were as follows:soaking extracted 3 times with 10 times the amount of 60% ethanol at 50℃. HPD-500 type macro porous resin showed better adsorption and desorption property

optimum purification conditions were as follows:sample solution was prepared with the concentration of 50 g · L-1

subjected to HPD-500 type macroporous resin column chromatography with load ratio of 16 mg total flavones per gram of resin

standing for 1 hour

column was eluted with 4 BV water before being eluted with 2 BV 70% ethanol.Under these conditions

purity of total flavones was 76.7%

which enhanced 3.83 times. Conclusion: This optimized technology was convenient and practical

it could provide a reference for industrial production of A. ageratoides.