Optimization of Prescription Technology of Kunshen Dispersible Tablet
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Optimization of Prescription Technology of Kunshen Dispersible Tablet
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 11, Pages: 34-36(2012)
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Published:2012
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ZHU Li-qiao, SHENG Hua-gang. Optimization of Prescription Technology of Kunshen Dispersible Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 34-36.
DOI:
ZHU Li-qiao, SHENG Hua-gang. Optimization of Prescription Technology of Kunshen Dispersible Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 34-36.DOI:
Optimization of Prescription Technology of Kunshen Dispersible Tablet
Objective: To optimize molding process of Kunshen dispersible tablet. Method: With disintegration time as index
type of excipients were optimized by single factor test and the amount of excipients was optimized by uniform design test. Result: Optimum formulation was composed of extract powder 65%
microcrystalline cellulose 21%
cross-linked polyvinyl polyrrolidone (PVPP) 12%
aspartame 2%.Under these conditions
disintegration time of formulation was less than 3 min
this tablet was dissolved quickly and completely. Conclusion: This optimized formulation was reasonable