Preparation of Baicalin Lipid Carrier Gel and Evaluation of its Transdermal Property

XIONG Xin; LIU Shu-zhi; XU Jia-yin; CHEN Yan-jun

您当前的位置：

首页 >

文章列表页 >

Preparation of Baicalin Lipid Carrier Gel and Evaluation of its Transdermal Property

更新时间：2024-01-04

- Preparation of Baicalin Lipid Carrier Gel and Evaluation of its Transdermal Property
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 12, Pages: 28-30(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
XIONG Xin, LIU Shu-zhi, XU Jia-yin, et al. Preparation of Baicalin Lipid Carrier Gel and Evaluation of its Transdermal Property[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 28-30.
DOI：

XIONG Xin, LIU Shu-zhi, XU Jia-yin, et al. Preparation of Baicalin Lipid Carrier Gel and Evaluation of its Transdermal Property[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 28-30. DOI：

摘要

目的: 制备黄芩苷脂质体凝胶与传递体凝胶

同时比较两者体外释透皮性能。方法: 以卡波姆981为辅料制备黄芩苷脂质体凝胶与传递体凝胶

采用改良Franz扩散池

以离体小鼠皮肤为透皮屏障

紫外分光光度法测定黄芩苷的单位面积累积透皮量。结果: 黄芩苷脂质体凝胶与传递体凝胶24 h单位面积累积透皮量分别为(38.00±2.51)

(43.27±2.39)μg·cm-2

体外释药特性均符合Higuchi动力学方程。结论: 在无压力条件下

黄芩苷传递体凝胶与普通脂质体凝胶具有相似的体外透皮性能。

Abstract

Objective: To prepare baicalin liposome gel and transfersome gel

and to compare in vitro transdermal property of them. Method: Baicalin liposome gel and transfersome gel were prepared with carbopol 981 as accessories

modified Franz diffusion cell was used

isolated rat skin as transdermal barrier

unit area cumulative permeation quantity of baicalin was determined by ultraviolet spectrophotometry. Result: Unit area cumulative permeation quantities of baicalein liposome gel and transfersome gel in 24 h were (38.00±2.51)

(43.27±2.39)μg·cm-2 respectively

in vitro transdermal property of them were in line with Higuchi pharmacokinetics equation. Conclusion: Without pressure

baicalin transfersome gel had similar in vitro tansdermal property with ordinary liposome gel.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Berberine-Baicalin Combination on Fecal Microbiota Transplantation-induced Type 2 Diabetes Mellitus Due to Internal Accumulation of Dampness-heat in Mice from Perspectives of Gut Microbiota and Metabolomics

Baicalin Induces Ferroptosis in Gastric Cancer Cells via p53-mediated SLC7A11 Down-regulation

Investigation of Effect of Polyethylene Glycol 400 on Pharmacokinetics and Anti-inflammatory Effect of Baicalin Based on UPLC-MS/MS and Molecular Docking Techniques

Synergistic Effect of Baicalin and Wogonoside on NF-κB Signaling Pathway Based on Medium-efficiency Equation

Atomization Characteristics of Baicalin， Ursodeoxycholic Acid and Caffeic Acid in Tanreqing Inhalation Solution

Related Author

CHEN Mengjie

LIU Yimin

ZHOU Yun

YU Keming

XIA Min

LIU Hongning

JI Yanhua

ZENG Zhijun

Related Institution

Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory， Jiangxi Province Key Laboratory of TCM Etiopathogenisis， Jiangxi University of Chinese Medicine

Henan Academy of Chinese Medicine

The Second Clinical Medical College， Henan University of Chinese Medicine

State Key Laboratory of Functions and Applications of Medicinal Plants，School of Pharmaceutical Sciences，Engineering Center of Microbiology and Biochemical Pharmacy，Experimental Animal Center，Guizhou Medical University

Chengdu University of Traditional Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰