Experiment Study on Anti-inflammatory Effect of Total Saponins from Root

YU Xiao-min; LIU Yu-ling; LIU Yong-ping; TONG Ji-ming

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Experiment Study on Anti-inflammatory Effect of Total Saponins from Root

更新时间：2024-01-04

- Experiment Study on Anti-inflammatory Effect of Total Saponins from Root
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 10, Pages: 227-229(2012)
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- Published：2012
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YU Xiao-min, LIU Yu-ling, LIU Yong-ping, et al. Experiment Study on Anti-inflammatory Effect of Total Saponins from Root[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(10): 227-229.
DOI：

YU Xiao-min, LIU Yu-ling, LIU Yong-ping, et al. Experiment Study on Anti-inflammatory Effect of Total Saponins from Root[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(10): 227-229. DOI：

摘要

目的: 评价赤雹根总皂苷(TSRT)的抗炎活性。方法: 二甲苯致小鼠耳肿胀实验

昆明种小鼠

随机分为TSRT 240

120

60 mg·kg-1剂量组

Asp 200 mg·kg-1组及模型对照组

连续ig给药3 d。角叉菜胶致大鼠足跖肿胀实验

Wistar大鼠

随机分为TSRT 200

100

50 mg·kg-1剂量组

Asp 160 mg·kg-1组及模型对照组

连续ig给药3 d。大鼠皮内色素渗出实验

分组及给药剂量同"大鼠足跖肿胀实验"

ig给药1次。小鼠棉球肉芽肿实验

分组及给药剂量同"小鼠耳肿胀实验"

连续ig给药7 d 。以耳肿胀度、足跖肿胀度、色素渗出量及肉芽肿质量为指标评价TSRT对急、慢性炎症的影响。结果: 在小鼠耳肿胀实验中

TSRT 240

120

60 mg·kg-1剂量组小鼠耳肿胀度均明显低于模型对照组(P＜0.01);在大鼠足跖肿胀实验中

致炎后1~4 h

TSRT 200

100 mg·kg-1剂量组大鼠足趾肿度均明显低于模型对照组(P＜0.01)

致炎后2~4 h

TSRT 50 mg·kg-1剂量组大鼠足趾肿度均明显低于模型对照组(P ＜0.05);大鼠皮内色素渗出实验中

各剂量组皮内蓝斑的面积及色素渗出量均低于模型对照组(P ＜0.05~P<0.01);大鼠棉球肉芽肿质量显著低于模型对照组(P<0.05~P<0.01)。结论: 赤雹根总皂苷对急慢性炎症有明显的抗炎作用。

Abstract

Objective: To investigate the anti-inflammatory effect of total saponins of the root from Thladiantha dubia Bunge(TSRT). Method: The experiment of xylene-induced ear swelling in mice

carrageenin-induced paw edema in rats

histamine-induced pigment oozing from skin vessel in rats and cotton pellet granuloma in mice were used to investigate the effect of TSRT on acute and chronic inflammation. Result: In mice ear swelling test

the ear swelling degree in all TSRT dose groups was lower than that in model group (P＜0.01). In the test of carrageenin-induced paw edema in rats

at 1-4 h after carrageenin-induced inflammatory

paw edema degree in TSRT 200 mg·kg-1 and 100 mg·kg-1 groups were significantly lower than that in mode group (P＜0.01)

at 2-4 h after carrageenin-induced inflammatory

paw edema degree in TSRT 50 mg·kg-1 group was lower than that in model group (P＜0.05). In the test of histamine-induced pigment oozing from skin vessel in rats

in all TSRT dose groups

the pigment infiltration area and pigment content were lower than that in model group(P＜0.05-P<0.01). In the test of mice cotton pellet granuloma

weight of cotton pellet granuloma was lower than that in model group(P<0.05-P<0.01). Conclusion: TSRT has significent anti-inflammatory on acute and chronic inflammatory.

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ZHANG Yu-ling

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MAO Xiao-xia

LIU Yong-ping

DENG Yi

QIAN Zi-gang

Related Institution

Chengde Medical College

Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-yao

Henan University of Chinese Medicine

Medical School， Lijiang Culture and Tourism College

Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao， Henan University of Chinese Medicine

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