Objective: To observe Wushen Shunmai capsule combined with low dose amiodarone on maintenance of sinus rhythm

P wave dispersion(Pd)

left atrial diameter (LAD) and left ventricular shoot ejection fraction (LVEF) in patients with paroxysmal atrial fibrillation(PAF) after the restoration of sinus rhythm. Method: PAF patients (100 patients)

who received intravenous amiodarone converted to sinus rhythm

were randomly divided into two groups

the control group (50 patients) was received oral low dose amiodarone alone

the treatment group was received Wushen Shunmai capsule on the basis of the control group.Two groups were treated continuously for 6 months. Result: There were no significant difference on rate of sinus rhythm maintenance in 15 d

1 month after maintenance of sinus rhythm therapy between the two groups

the sinus rhythm maintenance rates of the treatment group(85.1%

80.9%) were significantly higher than the control group (71.1%

57.8%) at 6

12 months after maintenance of sinus rhythm therapy

(allP<0.05). At 12 months after maintenance of sinus rhythm therapy the Pmax

Pd

LAD of the treatment group was significantly shorter than before treatment(P<0.01) and the control group(all P<0.05). The LVEF of the treatment group was significantly higher than that before treatment(P<0.01) and the control group (P<0.05);Wushen Shunmai capsule had no adverse reaction. Conclusion: It was the good effect with safety that Wushen Shunmai capsule combination with low dose amiodarone for paroxysmal atrial fibrillation to maintain sinus rhythm

better than amiodarone alone

significantly reducing the maximum P wave duration and P wave dispersion

reduce the left atrial diameter

and improve left ventricular ejection fraction.