The Effect of Zhishi Xiebai Guizhi Decoction on Lipid Metabolism and Vscular Endothelium in Hyperlipidemia Rat

XIA Han-xin; ZHANG Ye

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The Effect of Zhishi Xiebai Guizhi Decoction on Lipid Metabolism and Vscular Endothelium in Hyperlipidemia Rat

更新时间：2024-01-04

- The Effect of Zhishi Xiebai Guizhi Decoction on Lipid Metabolism and Vscular Endothelium in Hyperlipidemia Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 10, Pages: 224-226(2012)
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- Published：2012
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XIA Han-xin, ZHANG Ye. The Effect of Zhishi Xiebai Guizhi Decoction on Lipid Metabolism and Vscular Endothelium in Hyperlipidemia Rat[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(10): 224-226.
DOI：

XIA Han-xin, ZHANG Ye. The Effect of Zhishi Xiebai Guizhi Decoction on Lipid Metabolism and Vscular Endothelium in Hyperlipidemia Rat[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(10): 224-226. DOI：

摘要

目的: 观察枳实薤白桂枝汤对高脂血症大鼠血脂及血管内皮功能的影响。方法: 以高脂饲料喂养建立高脂血症大鼠模型;分正常、模型、西药组、不同剂量中药干预组

共6组;西药组给予普伐他汀钠(3.6 mg·kg-1)灌胃

中药干预分别给予高(7.2 g·kg-1)、中(3.6 g·kg-1)、低剂量(1.8 g·kg-1)枳实薤白桂枝汤灌胃3周;测定总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-c)、低密度脂蛋白(LDL-c);一氧化氮(NO)、内皮素(ET-1)的含量。结果: 与正常组比较

模型组大鼠血清TC

LDL-C均显著升高(P<0.01)

HDL-C降低(P<0.05);血清NO水平降低(P<0.05)

血浆ET-1水平升高(P<0.05)。与模型组相比

普伐他汀钠组、枳实薤白桂枝汤高剂量组TC

LDL-C均显著降低(P<0.01)

枳实薤白桂枝汤中、低剂量组TC

LDL-C均降低(P<0.05)

中剂量组TG降低(P<0.05);用药各组对HDL-C均无明显影响。普伐他汀钠组、枳实薤白桂枝汤高剂量组NO明显升高(P<0.05)

普伐他汀钠组ET-1明显降低(P<0.05)。结论: 枳实薤白桂枝汤可明显降低高脂血症大鼠TC

TG和LDL-C含量

提高血清NO水平

对ET-1的释放没有明显影响。枳实薤白桂枝汤具有降血脂及部分改善血管内皮功能的作用。

Abstract

Objective: To investigate the effects of Zhishi Xiebai Guizhi decoction on lipid metabolism and vscular endothelium in hyperlipidemia rat. Method: Using hyperlipidemia animal model replicated by hyperlipidemia forage

pravastatin sodium (3.6 mg·kg-1)and different doses of Zhishi Xiebai Guizhi decocotion (7.2

3.6

1.8 g·kg-1) were given to the model rats. Then the levels of total cholesterol(TC)

triglycerides(TG)

high-density liporotein cholesterol(HDL-C)

low-density lipoprotein cholesterol(LDL-C) and levels of nitric oxide(NO)

endothelin-1(ET-1) were assayed. Result: Compared with the normal group

the levels of TC

LDL-C in the model group were increased obviously

the level of NO was decreased

the level of ET-1 was increased.Compared with the model group

the levels of TC

LDL-C in the Zhishi Xiebai Guizhi decocotion high dose group and the pravastatin sodium group were decreased obviously

the level of NO was increased obviously

the level of ET-1 were decreased obviously. Conclusion: The Zhishi Xiebai Guizhi decocotion can regulate the lipid metabolism and improve vascular endothelium function in rat with hyperlipidemia.

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Related Institution

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Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory/Jiangxi Province Key Laboratory of Biological Etiologies of TCM/First-Level Discipline Platform of Chinese and Western Integrative Medicine/Experimental Animal and Scientific Technology Center of Jiangxi University of Chinese Medicine/School of Pharmacy， Jiangxi University of Chinese Medicine

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