Pharmaceutical Evalution of Injectable Shenmai Temperature-sensitive in Situ Gel

XU Jia-yin; XIONG Xin; CHEN Yan-jun

您当前的位置：

首页 >

文章列表页 >

Pharmaceutical Evalution of Injectable Shenmai Temperature-sensitive in Situ Gel

更新时间：2024-01-04

- Pharmaceutical Evalution of Injectable Shenmai Temperature-sensitive in Situ Gel
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 13, Pages: 60-64(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
XU Jia-yin, XIONG Xin, CHEN Yan-jun. Pharmaceutical Evalution of Injectable Shenmai Temperature-sensitive in Situ Gel[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 60-64.
DOI：

XU Jia-yin, XIONG Xin, CHEN Yan-jun. Pharmaceutical Evalution of Injectable Shenmai Temperature-sensitive in Situ Gel[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 60-64. DOI：

摘要

目的: 制备可注射用参麦温度敏感型原位凝胶制剂

并考察其体外释放特性。方法: 采用冷溶法制备参麦温度敏感型原位凝胶制剂

HPLC测定人参皂苷Rb1含量

以透析法研究参麦温度敏感型原位凝胶的体外释放特性

并利用药物释放模型方程拟合释放曲线。结果: 参麦温度敏感型原位凝胶的胶凝温度34.92℃

相应黏度1579.52 mPa·s

胶凝时间110.67 s。随温度升高

该原位凝胶由牛顿流体转变为假塑性流体

其体外释放行为符合一级动力学方程。结论: 参麦温度敏感型原位凝胶具有温敏特性及明显的缓释作用。

Abstract

Objective: To prepare injectable Shenmai thermosensitive in situ gel and to investigate its in vitro release characteristics. Method: Shenmai thermosensitive in situ gel was prepared by cold dissolution method

the content of ginsenoside Rb1 was determined by HPLC

in vitro release characteristics of Shenmai thermosensitive in situ gel was investigated by dialysis method

and release curve was fitted by drug release model equation. Result: Gelation temperature was 34.92℃

corresponding viscosity value was 1579.52 mPa·s

gelation time was 110.67 s. This in situ gel showed a newtonian fluid at a low temperature while it might be a pseudoplastic fluid when the temperature reached a certain point

in vitro release of Shenmai thermosensitive in situ gel fitted first order kinetics equation. Conclusion: Shenmai thermosensitive in situ gel had temperature sensitivity and obviously sustained-release effect.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Optimization and Evaluation of Baicalin Thermosensitive Gels for External Application

Related Author

LIANG Hao-ming

LONG Xiao-ying

LU Bin

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰