Optimization of Preparation Technology for Huanglian Ointment
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Optimization of Preparation Technology for Huanglian Ointment
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 17, Pages: 36-38(2012)
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Published:2012
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GUAN Zhi-yu, CEHN Li-hua, WANG Sen, et al. Optimization of Preparation Technology for Huanglian Ointment[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 36-38.
DOI:
GUAN Zhi-yu, CEHN Li-hua, WANG Sen, et al. Optimization of Preparation Technology for Huanglian Ointment[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 36-38.DOI:
Optimization of Preparation Technology for Huanglian Ointment
Objective: To optimize preparation process of Huanglian ointment. Method: With yield of extract
the content of total alkaloid and composite score as indexes
extraction technology was optimized by orthogonal test with the concentration of ethanol
solid-liquid ratio
extraction time and extraction times as factors; Effect of five different ointment matrix prescriptions on formation and quality of Huanglian ointment was compared by stability experiment. Result: Optimum extraction process was:extracted 2 times with 6 times the amount of 70% ethanol
1.5 h per time;Ointment matrix composition as follows:octadecanol
liquid paraffin
white petrolatum
glycerin monostearate
Tween-80
Span-60
glycerin
double distilled water. Conclusion: This optimized extraction technology and ointment molding process was stable and feasible