Objective: To compare the effects of three different prescription granules of Semen Cassiae prepared by spraying

freezing and vacuum process methods and traditional decoction

and to provide theoretical basis for clinical application. Method: The mice were divided into normal group

model group

positive control group

Semen Cassiae decoction group and spray group

frozen group

vacuum group of granules. The actions on intestinal propulsion in normal mice

defecation of dry constipation in constipation mice

and blood lipids in hyperlipidemia mice (including TC

TG

HDL-C

LDL-C) were observed to find the pharmacological differences at same dose. Result: Three granules significantly promoted intestinal movement in normal mice(P<0.01); but showed not evident difference compared with the decoction. Three granules groups promoted bowel movement in constipation mice

the first black fecal discharge time in spraying group and freezing group shortened evidently compared with the decoction(P<0.01 and P<0.05). Compared with hyperlipidemia model group

TC and LDL-C in spraying and freezing groups reduced (P<0.05)

but HDL-C increased evidently(P<0.05)

TG levels in freezing group also reduced evidently(P<0.05)

the vacuum and decoction groups only showed significant differences in TC level(P<0.05). Conclusion: Semen Cassiae granules are superior to the traditional decoction in efficacy

especially freezing and spraying granules indicate more significant effects.