Study on Antifebrile Parts for Chaiqin Decoction

YANG Jiang-ping; GAO Zeng-ping; XIE Ming

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Study on Antifebrile Parts for Chaiqin Decoction

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- Study on Antifebrile Parts for Chaiqin Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 14, Pages: 131-134(2012)
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- Published：2012
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YANG Jiang-ping, GAO Zeng-ping, XIE Ming. Study on Antifebrile Parts for Chaiqin Decoction[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 131-134.
DOI：

YANG Jiang-ping, GAO Zeng-ping, XIE Ming. Study on Antifebrile Parts for Chaiqin Decoction[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 131-134. DOI：

摘要

目的: 比较分离的柴胡-黄芩水提液各有效部位对脂多糖诱导的发热小鼠模型的退热影响。方法: 柴胡-黄芩水提液经AB-8型大孔树脂柱净化

依次用水

20%

40%

60%和90%乙醇梯度洗脱

通过化学反应检识

合并组成相近的流份得到4个部位;观察各部位对脂多糖诱导的小鼠发热模型的退热作用。结果: 柴胡-黄芩水提液经分离得到的4个部位分别为糖类(A)、皂苷类(B)、皂苷及黄酮苷类(C)、黄酮苷元及皂苷元(D);4个部位均具有不同程度的退热作用(P <0.05)

其中以D部位的退热作用最好(P <0.01)。结论: 柴胡-黄芩水提液退热作用涉及多个部位。

Abstract

Objective: This study was designed to evaluate the effect of the antipyretic effective fraction from the decoction of Bupleurum chinese and Scutellaria baicalensis in fever model mice induced by lipopolysacharide(LPS). Method: Four fractions were obtained by using AB-8 macroporous resin column to purify the decoction of B. chinese and S. baicalensis . Through chemical reactions to dentify the major types of components

the flow of a merger similar gain four parts.Then the anus temperature of mice was tested to observe the antifebrile action of every fraction and compare to the fever model mice induced by LPS. Result: The four fractions

A (polysaccharides)

B (saponins)

C (saponins and flavonoids)

D (flavonoids and aglycones of saponins)

purified by AB-8 macroporous resin

all can reduce the temperature of fever mice (P<0.05)

and diferent fraction have differen levels. Fraction D showed the best effective on antifebrile action(P<0.01). Conclusion: the decoction of B. chinese and S. baicalensi s involved more than one effect of the fever effective fractions.

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Related Institution

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