Objective: To observe the effect of Qinggan Tiaozhi decoction on lipid peroxidatic reaction in rat nonalcoholic steatohepatitis(NASH). Method: The NASH model was induced by high fat diet

and the modeling rats were randomly divided into five groups: the model group

the low dose

middle dose and high dose group of Qinggan Tiaozhi decoction and the group of silybin

each group were treated with corresponding 4.59

9.18

18.39 g·kg-1 and 27 mg·kg-1

ig. The indexes of alanine aminotransferase(ALT)

aspartate aminotransferase(AST) and triglyceride(TG) in serum were detected

the levels of tumor necrosis factor alpha (TNF-α)

malondialdehyde (MDA) and superoxide dismutase (SOD) in liver tissue homogenate were measured

CD14 and cytochromes P450 2E1(CYP2E1) in liver tissue for quantitative analysis were assayed by immunohistochemical stain. Result: The indexes of ALT

TNF-α

CYP2E1 and SOD in model group were changed compared with those in normal group (P<0.05

P<0.01)

otherwise they were all improved in treated groups than those in model group (P<0.05

P<0.01). The indexes of TG and TNF-α were improved in high dose group of Qinggan Tiaozhi decoction than that in silybin group (P<0.01)

and for other indexes

there were similar effects between Qinggan Tiaozhi decoction and silybin group. Conclusion: Compared with silybin

Qinggan Tiaozhi decoction has better effects on NASH.