Technology Optimization of Inclusion Compound for Volatile Oil from  with Hydroxypropyl--cyclodextrin

ZHU Ying; YU Di-jia

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Technology Optimization of Inclusion Compound for Volatile Oil from with Hydroxypropyl--cyclodextrin

更新时间：2024-01-04

- Technology Optimization of Inclusion Compound for Volatile Oil from with Hydroxypropyl--cyclodextrin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 17, Pages: 28-31(2012)
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- Published：2012
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ZHU Ying, YU Di-jia. Technology Optimization of Inclusion Compound for Volatile Oil from with Hydroxypropyl--cyclodextrin[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 28-31.
DOI：

ZHU Ying, YU Di-jia. Technology Optimization of Inclusion Compound for Volatile Oil from with Hydroxypropyl--cyclodextrin[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 28-31. DOI：

摘要

目的: 优选蛇床子挥发油羟丙基-β-环糊精(HP-β-CD)包合物的制备工艺。方法: 以挥发油利用率和包合物得率为考察指标

采用正交试验法对蛇床子挥发油HP-β-CD包合物的工艺进行优化。采用UV技术、显微鉴定、GC-MS技术对包合物进行质量控制研究。结果: 最佳包合工艺条件为蛇床子挥发油与HP-β-CD的体积质量比1∶8

包合时间2.0 h

包合温度40 ℃。采用紫外光谱法验证包合前后紫外吸收图谱基本一致

显微鉴定表明油已被包合

GC-MS验证了包合前后挥发油中各成分基本未发生变化。结论: 该提取、包合工艺合理可行

为临床制剂的合理使用和包合物开发提供实验依据。

Abstract

Objective: To optimize preparation technology of inclusion compound of volatile oil from Cnidium monnieri with hydroxypropyl-β-cyclodextrin (HP-β-CD). Method: With utilization rate of volatile oil and yield of inclusion compound as indexes

inclusion compound of volatile oil from C. monnieri with HP-β-CD was optimized by orthogonal design.Quality control of inclusion compound was studied by UV technology

microscopic identification and GC-MS analysis. Result: Optimum inclusion technology was:volatile oil to HP-β-CD 1∶8(mL·g-1)

inclusion time 2.0 h

inlusion temperature 40 ℃.It verified that UV absorption spectrum was the same before and after inclusion

volatile oil had been inclusion by microscopic identification

GC-MS verified that composition in volatile oil was essentially unchanged before and after inclusion. Conclusion: Both of extraction and inclusion technology were reasonable and feasible

it could provide experimental basis for rational use of clinical formulation and development of inclusion.

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Related Author

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LIU Zhi-qi

GONG Mu-xin

HAO Jing-jing

LI Hai-liang

Related Institution

College of Life Science and Engineering,Lanzhou University of Technology

Department of Pharmacology,School of Basic Medicine,Capital Medical University

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