Objective: To study the therapeutic effects of Kangxian capsule

a Chinese patent medicine

on the hepatic fibrosis in rats. Method: Forty male SD rats were randomly divided into normal control group

model group

colchicine group

Kangxian capsule high dose and low dose group. In order to prepare the hepatic fibrosis model

all the rats except those of the normal control group were subcutaneously administrated with the CCL4 olive oil solution for six weeks and were given high-fat diet in the first two weeks. The treatment groups were given different doses of Kangxian capsule and colchicine intervention for six weeks. The control group and model group animals were intragastrically fed with the same volume of normal saline. The activities of alanine aminotransferase(ALT) and aspartate aminotransferase(AST) in rat sera were detected with automatic biochemistry analyzer. The concentrations of hyaluronic(HA)

laminin(LN)

typeⅢ procollagen (PCⅢ)in sera were measured with the method of radioimmunoassay.The pathohistological changes were observed under microscope. Result: Compared with the model group

the serum levels of ALT

AST

HA

LN

PCⅢ in rats of Kangxian capsule treatment groups were significantly lower(P<0.01).There were much degeneration and necrosis

inflammatory cell infiltration

false lobular formation

and a large number of collagen fiber depositions in liver tissue of the model group. Compared with the model group

the level of chronic hepatic damage was improved greatly and none of the false lobular formed in two dose of Kangxian capsule groups. Conclusion: Kangxian capsule can greatly protect from hepatic fibrosis in rats induced by CCL4.