Effects of Naomaishukang Capsule on Rat Stasis Model Combined Cerebral Ischemia in the Energy Metabolism

BAI Ming; GAO Xiao-ling; MIAO Ming-san

您当前的位置：

首页 >

文章列表页 >

Effects of Naomaishukang Capsule on Rat Stasis Model Combined Cerebral Ischemia in the Energy Metabolism

更新时间：2024-01-04

- Effects of Naomaishukang Capsule on Rat Stasis Model Combined Cerebral Ischemia in the Energy Metabolism
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 11, Pages: 209-211(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
BAI Ming, GAO Xiao-ling, MIAO Ming-san. Effects of Naomaishukang Capsule on Rat Stasis Model Combined Cerebral Ischemia in the Energy Metabolism[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 209-211.
DOI：

BAI Ming, GAO Xiao-ling, MIAO Ming-san. Effects of Naomaishukang Capsule on Rat Stasis Model Combined Cerebral Ischemia in the Energy Metabolism[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 209-211. DOI：

摘要

目的: 探讨脑脉舒康胶囊对大鼠血瘀合并脑缺血模型能量代谢的影响。方法: 采用注射地塞米松复制血瘀模型

模型大鼠灌服脑脉舒康胶囊0.9

0.6

0.3 g·kg-1连续10 d

于第11天给药后1 h

结扎大鼠两侧颈总动脉30 min

制造脑缺血模型;取大鼠脑组织匀浆

检测脑匀浆液Na+K+-ATPase

Mg2+-ATPase

Ca2+-ATPase活力、乳酸(LD)含量、乳酸脱氢酶(LDH)活力。结果: 脑脉舒康胶囊3个剂量组均可以提高模型大鼠脑组织ATP活力(P<0.01或P<0.05)

高剂量和中剂量组可以降低LD含量(P<0.01)

中剂量和低剂量组可以提高LDH活力(P<0.01)。结论: 脑脉舒康胶囊对大鼠血瘀合并脑缺血模型能量代谢有改善作用

减少乳酸堆积

可以减轻组织结构及功能损伤。

Abstract

Objective: To study the effects of Naomai Shukang capsule on energy metabolism in rat blood stasis with cerebral ischemia models. Method: Blood stasis model was replicated with injection of dexamethasone. Model rats were administrated orally with Naomai Shukang capsule according to dosages of 0.9

0.6

0.3 g·kg-1 for 10 d. After the rats were administrated with drugs for 1 h on the 11th day

Cerebral ischemia models were made by ligating both sides of the common carotid arteries of rats for 30 min. Na+-K+-ATPase

Mg2+-ATPase

Ca 2+-ATPase activity

lactic acid(LD) content and lactate dehy drogenase(LDH) activity of brain homogenates were measured. Result: Three doses of Naomai Shukang capsule can improve the ATP activities(P<0.01 or P<0.05). The high and medium dose can reduce the LD content(P<0.01). The medium and low dose can increase the LDH activity(P<0.01). Conclusion: Naomai Shukang capsule can improve brain energy metabolism in rat blood stasis with cerebral ischemia models and reduce lactic acid accumulation and damage to brain tissue.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Experimental Study of Naomai Shukang Capsule on Transient Ischemic Attack in Mice

Changes in Brain Energy Metabolism for Different Duration of Cerebral Ischemia in Rats

Multidimensional Analysis of Mechanisms of Nuciferine Against Cerebral Ischemia Based on Transcriptomic Data

Connotation and Prevention Strategies of Traditional Chinese Medicine for Panvascular Diseases

Related Author

LIU Ming

SUN Jian-ning

DONG Shi-fen

LIU Yang

XUAN Zhen-yu

LIU Ming1

SUN Jian-ning1

DONG Shi-fen1

Related Institution

Department of Traditional Chinese Medicine

贵阳中医学院

苏州玉森新药开发有限公司

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

School of Basic Science，Shanxi Key Laboratory for Modernization of Traditional Chinese Veterinary Medicine，Shanxi Agricultural University

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰