Hypotensive Effect of the Alcohol Extract from Gouteng Prescription on Spontaneous Hypertensive Rats
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Hypotensive Effect of the Alcohol Extract from Gouteng Prescription on Spontaneous Hypertensive Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 11, Pages: 216-218(2012)
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Published:2012
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SONG Xue-yun. Hypotensive Effect of the Alcohol Extract from Gouteng Prescription on Spontaneous Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 216-218.
DOI:
SONG Xue-yun. Hypotensive Effect of the Alcohol Extract from Gouteng Prescription on Spontaneous Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 216-218.DOI:
Hypotensive Effect of the Alcohol Extract from Gouteng Prescription on Spontaneous Hypertensive Rats
Objective: To explore the hypotensive effects and mechanisms of the alcohol extract from Gouteng prescription. Method: Thirty spontaneous hypertensive rats (SHR) were randomly divided into five groups
untreated control
the high
middle
low dosage group of the alcohol extract and captopril group
six rats in each group. Tail blood pressure was measured every week. Rats were sacrificed to determine serum(NO)
ET
AngⅡ after six weeks of treatment. Result: The alcohol extract from Gouteng prescription significantly lowered the blood pressure of rats
meanwhile significantly increased NO content
decreased markedly the content of ET
but it could not decrease AngⅡ. Conclusion: Alcohol extract from Gouteng prescription had significant hypotensive effect in SHR and its mechamsim may relate to increasing NO content and reducing ET level.