The Effects of Xinmailong Capsules on Blood Lipid Level and Hepatic Lipid in Rats with Hyperlipemia
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The Effects of Xinmailong Capsules on Blood Lipid Level and Hepatic Lipid in Rats with Hyperlipemia
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 12, Pages: 225-228(2012)
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Published:2012
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XIAO Fen, WU Jian-xin, REN Hai-hua. The Effects of Xinmailong Capsules on Blood Lipid Level and Hepatic Lipid in Rats with Hyperlipemia[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 225-228.
DOI:
XIAO Fen, WU Jian-xin, REN Hai-hua. The Effects of Xinmailong Capsules on Blood Lipid Level and Hepatic Lipid in Rats with Hyperlipemia[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 225-228.DOI:
The Effects of Xinmailong Capsules on Blood Lipid Level and Hepatic Lipid in Rats with Hyperlipemia
Objective: To observe the effects of Xinmailong capsules(XMLJ) on the blood lipid and hepatic tissue in the rats with hyperlipidemia. Method: The hyperlipidemia model was established by injected intraperitoneally(ip) vitamin D 6×105 IU·kg-1 at once and given high fat forage for four weeks. Then modeling rats were treated with different doses of XMLJ(450
300
150 mg·kg-1)
and four weeks later
the levels of blood lipid were measured
the degree of peroxide and endothelium injury were observed
including the hepatic tissue pathology. Result: The total cholesterol(TC)
triglyeeride(TG)
low density lipoprotein-cholesterol(LDL-C) and malondialdehyde(MDA)
endothelin-1(ET-1)
thromboxane B2(TXB2) at different dosages of XMLJ were significantly decreased
and the high density lipoprotein-cholesterol(HDL-C)
nitric oxide(NO)
prostacyclin (PGI2)with XMLJ were markedly increased
meanwhile
it could increase SOD activity
steatosis of hepatic tissue was significantly reduced. Conclusion: XMLJ could regulatedblood lipid level
improve antioxidation ability
enhance vascular endothelial function and relieve the liver steatosis.
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Related Institution
School of Chinese Materia Medica, Beijing University of Chinese Medicine
Institute of Scientific Research,Beijing Tongrentang Company Limited by Shares
Dongfang Hospital, Beijing University of Chinese Medicine
Key Laboratory of Basic and Applied Research on Northern Medicine, Ministry of Education, Experimental Teaching and Training Center, Heilongjiang University of Chinese Medicine