Investigation of Release Rate of  Oil Self-microemulsion

KONG Fan-sheng; YAN Chun-yan; BEN Yong-guang; LI Dan-xia; SHAO A-li

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Investigation of Release Rate of Oil Self-microemulsion

更新时间：2024-01-04

- Investigation of Release Rate of Oil Self-microemulsion
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 12, Pages: 21-23(2012)
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- Published：2012
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KONG Fan-sheng, YAN Chun-yan, BEN Yong-guang, et al. Investigation of Release Rate of Oil Self-microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 21-23.
DOI：

KONG Fan-sheng, YAN Chun-yan, BEN Yong-guang, et al. Investigation of Release Rate of Oil Self-microemulsion[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 21-23. DOI：

摘要

目的: 建立鸦胆子油自微乳溶出度的测定方法。方法: 采用气相色谱法测定鸦胆子油中油酸的含量

以确定鸦胆子油自微乳化制剂溶出度测定的最佳条件。色谱条件为DB-FFAP毛细管柱(0.25 mm×30 m

0.25 μm)

进样口温度220 ℃

检测器温度220 ℃

柱温205 ℃

进样量1 μL。以0.1 mol·L-1HCl为溶出介质

硬胶囊壳为载体

转篮法测定鸦胆子油自微乳化给药系统的体外溶出度。结果: 鸦胆子油自微乳累积溶出度在15 min达90%。结论: 该测定方法准确可靠

可用于鸦胆子油自微乳的质量控制。

Abstract

Objective: To establish determination method of in virto release of Brucea javanica oil self-microemulsion. Method: The content of oleic acid from B. javanica oil was determined by GC method

to determine optimum conditions of dissolution determination of B. javanica oil self-microemulsion.Chromatographic conditions were:DB-FFAP capillary column (0.25 mm×30 m

0.25 μm)

column temperature of 205 ℃

temperture of inlet and detector were 220 ℃

sample volume 1 μL. 0.1 mol·L-1 HCl as dissolution medium

hard capsule shell as a carrier

in vitro release of B. javanica oil self-microemulsion drug delivery system was determined by rotating basket method. Result: Cumulative dissolution of B. javanica oil self-microemulsion was 90% in 15 min. Conclusion: This determination method was accurate and reliable

and it could be used for quality control of B. javanica oil self-microemulsion.

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Related Institution

Guangdong Pharmaceutical University

Shaanxi Academy of Traditional Chinese Medicine

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Dept.of Pharmacy,General Hospital Group Oilfield Hospital of Daqing

Yancheng Institute for Drug Control of Jiangsu Province

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