Objective: Compound Beimu powder was selected as model drug to investigate preparation and properties of multi-species and multi-texture traditional Chinese medicine (TCM) ultrafine powder in compound. Comparative study of powder characterization and physical properties between fine and ultrafine powder was investigated

in order to provide experimental basis for ultrafine grinding technology using in promotion and application of TCM compound. Method: With particle size and cell wall broken rate as indexes

particle size of drug levels of ultrafine powder was determined by laser particle size distribution instrument

ultrafine grinding process was selected.Apparent characterizations

microscopic appearances

particle size and specific surface areas were compared between fine and ultrafine powder. Meanwhile moisture absorption rate and angle of repose were determined to investigate hygroscopicity and mobility of fine and ultrafine powder. Result: Cell disruption rates were all above 95% when Ussuriensis fritillary

Chinese ephedra

Glycyrrhiza uralensis and Armeniaca amara were pulverized for one hour as well as Radices stemonae was pulverized for 40 minutes.Physical properties studies demonstrated that color of drug had shallow trend and its character was finer and smoother after ultrafine grinding

electron microscope scanning results showed that particle size distribution of ultrafine powder was narrower

simultaneously

some common microscoptical characters disappeared.Mobility of plant medicine reduced

however

mineral medicine increased.Hygroscopicity of U. Fritillary

C. ephedra and G. uralensis all demonstrated decreasing trend. Conclusion: Compared with fine powder

appearance

microscopic characteristics

mobility and moisture absorption of ultrafine powder were changed

this article could provide reference for processing of Chinese herbal ultrafine powder.