Effect of Absorption Enhancers on Intestinal Absorption of Silybin and its Phospholipid Complex

WEI Shi-jie; HUO Wu-zhen; WANG Li-bao

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Effect of Absorption Enhancers on Intestinal Absorption of Silybin and its Phospholipid Complex

更新时间：2024-01-04

- Effect of Absorption Enhancers on Intestinal Absorption of Silybin and its Phospholipid Complex
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 13, Pages: 43-46(2012)
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- Published：2012
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WEI Shi-jie, HUO Wu-zhen, WANG Li-bao. Effect of Absorption Enhancers on Intestinal Absorption of Silybin and its Phospholipid Complex[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 43-46.
DOI：

WEI Shi-jie, HUO Wu-zhen, WANG Li-bao. Effect of Absorption Enhancers on Intestinal Absorption of Silybin and its Phospholipid Complex[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 43-46. DOI：

摘要

目的: 考察吸收促进剂对水飞蓟宾及其磷脂复合物肠道吸收的影响。方法: 采用大鼠在体单向肠灌流法研究药物在大鼠的十二指肠、空肠、回肠及结肠的吸收情况。结果: 水飞蓟宾及其磷脂复合物在各肠段均有吸收

以空肠和回肠段吸收较好

且其磷脂复合物在各肠段吸收均高于药物本身。聚山梨醇酯对水飞蓟宾及其磷脂复合物无明显促进吸收作用

甘胆酸钠和卡波姆有较弱的吸收促进作用

十二烷基硫酸钠对水飞蓟宾具有较强的促进吸收作用

而对其磷脂复合物作用较弱;聚氧乙烯氢化蓖麻油对水飞蓟宾和磷脂复合物均有较强的促进作用。结论: 合理改善药物结构及选择适宜吸收促进剂能改善药物的吸收。

Abstract

Objective: To investigate effect of absorption enhancers on intestinal absorption of silybin and silybin phospholipid complex(SPC). Method: In siturats single pass perfusion model was uesd to investigate absorption of silybin and SPC in duodenum

jejunum

ileum and colon. Result: Silybin and SPC were absorbed in each intestinal segment

especially in jejunum and ileum

and absorption of SPC in each intestinal segments were higher than drug itself.Tween-80 had no significantly absorption enhancement effect on silybin and SPC

glycocholic acid sodium and carbomer only had silghtly promotion absorption

sodium dodecyl sulfate could greatly promote absorption of slilybin while weakly affected SPC;Cremophor RH40 had a strong role in promoting absorption of silybin and SPC. Conclusion: It could improve drug absorption by reasonable modifacaiton of drug structure and selection of suitable absorption enhancers.

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Related Institution

Key Laboratory of Modern Preparation of Traditional Chinese Medicine

西南交通大学材料先进技术教育部重点实验室

成都中医药大学

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