Effect and Mechanism of Shenling Baizhu San on the Murine Model of Inflammatory Bowel Disease Induced by Dextran Sodium Sulfate in Mice
|更新时间:2024-01-04
|
Effect and Mechanism of Shenling Baizhu San on the Murine Model of Inflammatory Bowel Disease Induced by Dextran Sodium Sulfate in Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 5, Pages: 136-140(2012)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2012
稿件说明:
移动端阅览
YOU Yu, LIU Yu-hui, GAO Shu-liang. Effect and Mechanism of Shenling Baizhu San on the Murine Model of Inflammatory Bowel Disease Induced by Dextran Sodium Sulfate in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(5): 136-140.
DOI:
YOU Yu, LIU Yu-hui, GAO Shu-liang. Effect and Mechanism of Shenling Baizhu San on the Murine Model of Inflammatory Bowel Disease Induced by Dextran Sodium Sulfate in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(5): 136-140.DOI:
Effect and Mechanism of Shenling Baizhu San on the Murine Model of Inflammatory Bowel Disease Induced by Dextran Sodium Sulfate in Mice
Objective: To investigate the effect and mechanism of Shenling Baizhu San on the murine model of inflammatory bowel disease(IBD) induced by dextran sodium sulfate. Method: IBD was induced by taking the drinking water added 5% dextran sodium sulphate (DSS) for 7 days. The BALB/c mice of different groups were ig administrated with normal sodium
5-aminosalicylic acid (5-ASA)
Shenling Baizhu San (12
6
3 g·kg-1)
respectively. Body weight
feces description
hemafecia
disease activity scoring(DAI)
reactive oxygen species (ROS)
myeloperoxidase(MPO)
content of malondialdehyde (MDA) in bowel tissue and histological scoring
and expression of TNF-α
IL-1β
IL-6 protein were observed. Result: Levels of ROS
MPO and MDA in DSS induced group were increased significantly and expression of tumor necrosis factor-α(TNF-α)
interleukin-1β(IL-1β)
interleukin-6(IL-6) protein were also increased. Three doses of Shenling Baizhu San could decrease ROS
MDA and MPO content
down-regulate TNF-α
IL-1β
IL-6 protein expression. Conclusion: Shenling Baizhu San can protect the damage in DSS-induced IBD in mice
which may be related to regulating inflammatory factor and scavenging oxygen free radicals.
Effect of Shenling Baizhu San on Murine Model of IBD Induced by DSS in Mice Through Regulating of Autophagy
Effect of Chaihu Shugan Decoction on Content of 5-HT and Expression of IL-1 mRNA IL-6 mRNA of Hippocampus in Chronic Temporal Lobe Epilepsy-deoression Modle Rats
Evaluation of Safety of Compound Kushen Injection and Efficacy in Treatment of Inflammatory Bowel Disease Based on Zebrafish Model
Traditional Chinese Medicine Intervention for Ferroptosis in Treatment of Inflammatory Bowel Disease: A Review
Treatment of Inflammatory Bowel Disease by Targeting M1/M2 Macrophage Polarization Balance with Traditional Chinese Medicine and Active Components: A Review
Related Author
Yu YOU
Yu-hui LIU
Wang-di LIAO
REN Zhi-jun
XIE Wei
LIU Yuan-zhen
ZHENG Yue-hui
CHEN Xiaolu
Related Institution
Jiangxi University of Traditional Chinese Medicine
The First Affiliated Hospital of Nanchang University
Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medical/Traditional Chinese Medicine(TCM) Processing Technology Inheritance Base of National Administration of TCM, School of Chinese Materia Medica, Beijing University of Chinese Medicine
Affiliated Hospital of Shandong University of TCM
Shandong University of Traditional Chinese Medicine(TCM)