Optimization of Preparation Technology for Binary Complexes of Rutin and Bismuth Microcapsules and Its Quality Evaluation

ZHANG Hui; YU Li-ping; PENG Guo-jiang; MA Hong-yu; LI Ming; WANG Bin; LI Qiang-guo

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Optimization of Preparation Technology for Binary Complexes of Rutin and Bismuth Microcapsules and Its Quality Evaluation

更新时间：2024-01-04

- Optimization of Preparation Technology for Binary Complexes of Rutin and Bismuth Microcapsules and Its Quality Evaluation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 13, Pages: 31-33(2012)
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- Published：2012
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ZHANG Hui, YU Li-ping, PENG Guo-jiang, et al. Optimization of Preparation Technology for Binary Complexes of Rutin and Bismuth Microcapsules and Its Quality Evaluation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 31-33.
DOI：

ZHANG Hui, YU Li-ping, PENG Guo-jiang, et al. Optimization of Preparation Technology for Binary Complexes of Rutin and Bismuth Microcapsules and Its Quality Evaluation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 31-33. DOI：

摘要

目的: 制备芦丁铋二元配合物微囊

并对其进行质量评价。方法: 利用自制的芦丁铋二元配合物为原料

采用复凝聚法制备芦丁铋二元配合物微囊

通过正交设计优选其制备工艺;通过包封率、验证性试验、粒径检查等对其进行质量评价。结果: 芦丁铋二元配合物微囊最佳制备条件为囊材与囊心物的质量比6:1

成囊pH 3.5

成囊温度60℃

固化时间1.5 h。结论: 应用优选工艺制备的微囊

其包封率>40%

重复性好

90%微囊粒径在15~85 μm。

Abstract

Objective: To prepare binary complexes of rutin and bismuth microcapsules

and evaluate its quality. Method: With homemade binary complexes of rutin and bismuth as raw material

binary complexes of rutin and bismuth microcapsules was prepared by complex coacervation method

preparation technology was optimized by orthogonal test;Quality evaluation was finished by detecting encapsulation efficiency

verification test and particle size. Result: Optimum preparation condition of binary complexes of rutin and bismuth microcapsules was:capsule material-capsule core 6:1

encysted pH 3.5

capsule temperature 60℃

curing time 1.5 h. Conclusion: Applying optimized technology to prepare microcapsules

encapsulation efficiency was more than 40% with good reproducibility

and particle size of 90% microcapsules was 15-85 μm.

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