Investigation of Dissolvability of Total Saponins from

CHEN Zhen-hua; GUAN Yong-mei; ZHANG Ni; WANG Sen; ZHU Wei-feng; YANG Ming

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Investigation of Dissolvability of Total Saponins from

更新时间：2024-01-04

- Investigation of Dissolvability of Total Saponins from
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 13, Pages: 28-30(2012)
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- Published：2012
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CHEN Zhen-hua, GUAN Yong-mei, ZHANG Ni, et al. Investigation of Dissolvability of Total Saponins from [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 28-30.
DOI：

CHEN Zhen-hua, GUAN Yong-mei, ZHANG Ni, et al. Investigation of Dissolvability of Total Saponins from [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 28-30. DOI：

摘要

目的: 考察白头翁总皂苷及其指标成分在不同试剂中的溶解情况

研究在各溶剂中

总皂苷溶解度、指标成分溶解度以及总皂苷分散情况三者之间的关系。方法: 运用沉淀法、指标成分含量测定法、粒径测定法对总皂苷溶解度、指标成分溶解度以及混悬液粒径进行测定。结果: 白头翁总皂苷及其指标成分在各溶剂中的溶解能力为甲醇>人工结肠液>人工小肠液>蒸馏水>人工胃液;混悬液粒径为人工胃液>蒸馏水>人工小肠液>人工结肠液>甲醇。结论: 白头翁总皂苷及其指标成分在甲醇中溶解度较大

人工胃液中相对最小

混悬液的粒径变化趋势与溶解度变化趋势基本呈反相关。

Abstract

Objective: To investigate dissolvability of total saponins from Pulsatilla chinensisand its index component in different dissolvents

and to study relationship among solubility of total saponins

solubility of index component and dispersion situation in various solvents. Method: Solubility of total saponins

solubility of index component and particle size of suspension was determined by precipitation method

index component determination method and particle size determination method. Result: Sequence of dissolvability of total saponins from P. chinensisand its index component in various solvents was:methanol>artificial colon juice>artificial small intestinal juice>distilled water>artificial gastric juice;particle size of suspension in sequence of artificial gastric juice>distilled water>artificial small intestinal juice>artificial colon juice>methanol. Conclusion: Dissolvability of total saponins from P. chinensisand its index component was maximum in methanol and minimum in artificial gastric juice

and relationship between change trend of particle size of suspension and solubility was basically negative correlation.

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Related Author

CHEN Zhen-hua1

GUAN Yong-mei3

ZHANG Ni3

OU Shui-ping1

ZHU Wei-feng3

YANG Ming1

YANG Shi-lin3

Hong-xing MA

Related Institution

College of Pharmacy,Chengdu University of Traditional Chinese Medicine

江西科技师范大学药学院

江西中医学院现代中药制剂教育部重点实验室

Jilin Agricultural University

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

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