Study on Hypoglycemic by

ZHANG Zhi-yong; GE Rui; LIU En-li; GAO Jian-ping

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Study on Hypoglycemic by

更新时间：2024-01-04

- Study on Hypoglycemic by
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 12, Pages: 215-218(2012)
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- Published：2012
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ZHANG Zhi-yong, GE Rui, LIU En-li, et al. Study on Hypoglycemic by [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 215-218.
DOI：

ZHANG Zhi-yong, GE Rui, LIU En-li, et al. Study on Hypoglycemic by [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 215-218. DOI：

摘要

目的: 研究日本毛连菜对正常小鼠及糖尿病模型小鼠血糖的影响。方法: 尾静脉注射四氧嘧啶50 mg·kg-1

72 h后血糖高于11.1 mmol·L-1为糖尿病模型。小鼠随机分为6组:正常组、模型组、消渴丸组(0.75 g·kg-1·d-1)、日本毛连菜低、中、高剂量组(1.5

6 g·kg-1·d-1)

ig给予药物14 d

测定空腹血糖

并进行了日本毛连菜急性毒性实验。结果: 给药14 d后

日本毛连菜水提物低、中、高剂量组的血糖值分别达到(7.52±1.47)

(7.33±2.99)

(7.79±1.84) mmol·L-1

与模型组比较有显著性差异(P<0.05)。急性毒性实验表明最大给药量为120 g·kg-1。结论: 日本毛连菜对实验性高血糖小鼠有明显降糖作用

且毒性较小。

Abstract

Objective: To investigate the effect of the water extract from Picris japoncia Thunb on blood glucose in normal mice and diabetic model mice. Method: Diabetic model in mice was induced by caudal vein injection of 50 mg·kg-1 alloxan. Mice were randomly divided into 6 groups: control group

model group

Xiaokewan pill group(0.75 g·kg-1·d-1)

low dose

moderate dose and high dose groupsof P. japoncia(1.5

6 g·kg-1·d-1).The drugs were administrated to mice for 14 days. Determination of fasting blood glucose by blood sampling

in the corresponding time

and acute toxicity experiment were carried out. Result: The blood glucose value of low dose

moderate dose and high dose group of P. japoncia achieved respectively was (7.52±1.47)

(7.33±2.99)

(7.79±1.84) mmol·L-1 after administrated for 14 days

there were significant difference in blood glucose value compared with model group.The acute toxicity experiment revealed that the maximum dose of intragastric administration was 120 g·kg-1. Conclusion: The total extracts of P. japoncia had obvious hypoglycemic activity and little toxicity in hyperglycemia model mice.

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Related Author

Li YAN

Hui GAO

Wei ZHENG

JI Min-chun

QIAN Qing-qing

QIAN Wei

SHEN Xiao-ying

YANG Yao-fang

Related Institution

（Chinese Materia Medica Processing Engineering and Technology Center of Liaoning Province， Key Laboratory of Processing Principle Analysis，National Administration of Traditional Chinese Medicine （TCM），School of Pharmacy，Liaoning University of TCM，，）

People’ Hospital of Wuxuan,Wuxuan

Prescriptions Module,Liaoning University of Traditional Chinese Medicine

Molecular Biology Laboratory,Liaoning University of Traditional Chinese Medicine

The Fifth People’s Hospital of Shanghai Fudan University

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