Objective: To study the protective effect of Pingweishu capsule on gastric mucosal injury in rats. Method: The rats were divided into control group

model group

Pingweishu capsule low (3.3 g·kg-1)

middle(6.6 g·kg-1)

high(6.6 g·kg-1) dose groups

Xue-dan-wei-chang pill group (22 g·kg-1) and ranitidine (50 mg·kg-1)group.After giving drugs a week

made the model of acute gastric ulcer in rat by Ethanol

observed the protective effect of Pingweishu Capsule on gastric mucosal injury with high

middle

low dose

and compared the effects with Xuedan- Weichang pill and ranitidine. Used gastrin(GAS) and motilin(MOT)reagent kit to test GAS and MOT content. Result: The stomach tissue lesions in rats was reduced significantly in Pingweishu capsule groups of high and middle dose(Compared with model group

P<0.01). The gastric tissues in high dose group were not significant changes in pathology

just as the normal control group and the group of Xuedan Weichang pill. But in low dose group there was only a little recovery. The GAS and MOT content of Pingweishu capsule groups was higher than that of the model group (Compared with model group

P<0.05 or P<0.01)

there was statistically significant difference.Compared with Xuedan Weichang pill group

there was not statistical significance

but high middle dose group of Pingweishu capsule had the trend of increasing the GAS and MTL. Conclusion: Pingweishu capsule could protect the induced gastric mucosal injury in rats by ethanol.