Objective: To prepare ellagic acid tablet

and to establish determination method for ellagic acid. Method: With appearance

hardness

friability and disintegration time of the tablet as indexes

prescription of ellagic acid tablet was optimized by orthogonal test; HPLC was adopted for determination of the content of ellagic acid

mobile phase of acetonitrile-0.1% phosphoric aid 23:77

flow rate of 0.8 mL·min-1

detection wavelength of 254 nm. Result: The best ratio of excipients from ellagic acid tablet was starch-lactose-hydroxymethyl starch sodium-magnesium stearate 4:9:0.5:0.2; There was a good linear relationship for ellagic acid tablet within the concentration of 10.21-102.10 mg·L-1

regression equation was Y=28010X-92942 (r=0.999 9)

average recovery rate was 98.12%

RSD 1.28%. Conclusion: This determination method was accurate

convenient

reliable

and it could be used for determination of ellagic acid from ellagic acid tablet.