Comparative of Chemical Properties and Pharmacodynamics Between Fine Powder and Ultra-Fine Powder of Compound Beimu Powder
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Comparative of Chemical Properties and Pharmacodynamics Between Fine Powder and Ultra-Fine Powder of Compound Beimu Powder
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 14, Pages: 39-43(2012)
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Published:2012
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YUE Da-yong, WANG Qiong, ZHANG Juan, et al. Comparative of Chemical Properties and Pharmacodynamics Between Fine Powder and Ultra-Fine Powder of Compound Beimu Powder[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 39-43.
DOI:
YUE Da-yong, WANG Qiong, ZHANG Juan, et al. Comparative of Chemical Properties and Pharmacodynamics Between Fine Powder and Ultra-Fine Powder of Compound Beimu Powder[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 39-43.DOI:
Comparative of Chemical Properties and Pharmacodynamics Between Fine Powder and Ultra-Fine Powder of Compound Beimu Powder
Objective: To compare chemical properties and pharmacodynamics between fine powder and ultra-fine powder of compound Beimu powder. Method: Change of chemical properties from fine powder and ultra-fine powder of Fritillaria ussuriensis
Ephedra sinica and Glycyrrhiza uralensis were investigated by determining the content of water-soluble and alcohol-soluble extract and active ingredients
thin layer chromatography (TLC) was used to identify these compounds. With cough latency and cough times of mice as indexes
antitussive effect of fine and ultra-fine powder was compared by ammonia induced cough in mice test. Result: Studies on chemical properties showed nature and content of main chemical composition from ultra-fine powder were not changed significantly.There was significantly inhibited of ultra-fine powder on mice cough which was caused by ammonia
it was more obvious by compared isodose fine powder of compound Beimu powder. Conclusion: Compared with fine powder
there was no obvious change of main chemical composition
but therapeutic effect improved 2 times
it could be reduce the dose of compound Beimu powder
results from this test would provide references for use of ultra-fine grinding technology in traditional Chinese medicine compound.
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