Objective: To explore the effect of Wuji Baifeng Wan on benign prostate hyperplasia (BPH) in mice. Method: Experimental prostatic hyperplasia mouse model was produced in the gonadectomy mouse by hypodermic injecting testosterone propionate 5 mg·kg-1·d-1 for 30 d. The model mice were divided into 5 groups

respectively were fed with 9

4.5

2.25 g·kg-1 Wuji Baifeng Wan suspension

450 mg·kg-1 longbishu capsule suspension and the same volume of normal saline solution. The blank control group was fed with the same volume of normal saline solution. Every group was given daily for 30 days. At two hours after the last administration

mice were sacrificed. The serum testosterone and estradiol levels

the prostate index and histomorphology changes of prostate gland

thymus gland that were observed. Result: Compared with model group

the Wuji Baifeng Wan at the dosage of 9

4.5

2.25 g·kg-1could reduce the testosterone and increase the estradiol levels observably. Levels of testosterone and estradiol in different groups were (2 713.2±1 282.8)

(3 767.2±1 044.9)

(4 350.2±1 632.9) nmol·L-1 and (131.9±36.0)

(78.4±34.9)

(80.2±26.2) nmol·L-1. Wuji Baifeng Wan at the dosage of 9

4.5

2.25 g·kg-1 could reduce the prostate indexes and alleviate the BPH observably. The volume density of prostate glands in different groups were (5.1±0.4)

(4.2±0.3)

(6.8±0.4). Wuji Baifeng Wan at the dosage of 9

4.5

2.25 g·kg-1 could incrassate thymus gland and increase the number of lymphocyte observably. Conclusion: Wuji Baifeng Wan have good therapeutic actions on gonadectomy BPH model caused by testosterone propionate in mice