Objective: To explore the effect of Ginkgo biloba tablets combined with methylcobalamin in treatment of diabetic peripheral neuropathy. Method: One hundred and forty-four patients with diabetic neuropathy were randomly divided into three groups: the treatment group(n=48)

the control group(n=48) and epalrestat group(n=48)

administered with G. biloba tablets combined with methylcobalamin

epalrestat combined with methylcobalamin

respectively

for 12 weeks. In the meantime

their other treatment was same.Then changes of nervous symptoms

physical signs and conduction velocity of the three groups were observed and estimated before and after the treatment. Result: The curative effect of treatment group was obviously superior to the control group in the total effective rate (81.82％ to 64.58％

P<0.05)and the sensory nerves conduction velocity(SNCV) and the motor nerve conduction velocity (MNCV) of median and peroneal nerves(P<0.05). Conclusion: These results suggest that G. biloba tablets combined with methylcobalamin has better efficacy in improving subjective symptoms

physical signs and nerve function than methylcobalamin in the treatment of diabetic neuropathy

providing a clinically significant means of treating diabetic neuropathy.