Progress of Research on Evaluation Methods for Pulmonary Inhalation Preparation
|更新时间:2024-01-04
|
Progress of Research on Evaluation Methods for Pulmonary Inhalation Preparation
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 11, Pages: 303-306(2012)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2012
稿件说明:
移动端阅览
HAN Fei, ZHAO Zhi-dong, WANG Yue-sheng, et al. Progress of Research on Evaluation Methods for Pulmonary Inhalation Preparation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 303-306.
DOI:
HAN Fei, ZHAO Zhi-dong, WANG Yue-sheng, et al. Progress of Research on Evaluation Methods for Pulmonary Inhalation Preparation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 303-306.DOI:
Progress of Research on Evaluation Methods for Pulmonary Inhalation Preparation
To provide research ideas and theoretical basis for relevant researches through summarizing on evaluation methods of pulmonary inhalation either in vivo or in vitro. Classifying various evaluation methods of pulmonary inhalation according to their characteristics after collecting
analyzing and concluding related 27 articles in last decade from the databases of CNKI
PubMed
ScienceDirect. Predominant evaluation methods were listed as follows:cascade impactor method
modern optic instruments method
pharmacodynamic evaluation method
pharmacokinetic evaluation method
intrapulmonary deposition method and so on. Currently
there were many problems yet to be solved for evaluation methods of pulmonary inhalation
for example
correlation between in vivo and in vitro evaluation methods was low
methods were single of pharmacodynamic and pharmacokinetic evaluation
animal models were not conforming to real situation of human body and safety assessment system was imperfect.All of these should be gradually improved and perfected in the future studies.