Objective: To investigate the mechanism of curative effect increased of Common Cnidium Fruit-Malaytea Scurfpea Fruit compatibility based on osthole and psoralen as the target components absorbed into the bloodstream. Method: The breast cancer bone metastasis nude mice models were established by injecting MDA-MB-231BO cells into left ventricular

and they were given different combinations of Common Cnidium Fruit-Malaytea Scurfpea Fruit drugs decoction

osthole and psoralen in nude ice plasma were detected by HPLC-MS

and the characteristics of osthole and psoralen absorbed into the bloodstream were observed. Result: The plasma osthole's ion peak could be found in the plasmas of Common Cnidium Fruit group; the psoralen molecule and its ion peak signal could be found in the plasmas of Malaytea Scurfpea Fruit group; osthole molecule and its ion peak signal

but not psoralen molecule or its ion peak signal could be found in the plasmas of Common Cnidium Fruit-Malaytea Scurfpea Fruit (1: 3) group; not only osthole molecule and its lon peak signal but also psoralen molecule and its lon peak signal could be found in the plasmas of Common Cnidium Fruit-Malaytea Scurfpea Fruit (2: 2) group; osthole molecule and its ion peak signal

but not psoralen molecule or its ion peak signal could be found in the plasmas of Common Cnidium Fruit-Malaytea Scurfpea Fruit (3: 1) group. Conclusion: Osthole and psoralen could be absorbed into the bloodstream

and the absorption into bloodstream of psoralen could be promoted by Common Cnidium Fruit and Malaytea Scurfpea Fruit 1: 1 compatibility.