The Effect of Liguzinediol on Hemodynamics in Rats with Acute Heart Failure Induced by Pentobarbital

GUO Yao; ZHOU Jing; BIAN Hui-min; Zhu Qing; LI Wei; WU Yan

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The Effect of Liguzinediol on Hemodynamics in Rats with Acute Heart Failure Induced by Pentobarbital

更新时间：2024-01-04

- The Effect of Liguzinediol on Hemodynamics in Rats with Acute Heart Failure Induced by Pentobarbital
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 6, Pages: 170-174(2012)
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- Published：2012
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GUO Yao, ZHOU Jing, BIAN Hui-min, et al. The Effect of Liguzinediol on Hemodynamics in Rats with Acute Heart Failure Induced by Pentobarbital[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 170-174.
DOI：

GUO Yao, ZHOU Jing, BIAN Hui-min, et al. The Effect of Liguzinediol on Hemodynamics in Rats with Acute Heart Failure Induced by Pentobarbital[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 170-174. DOI：

摘要

目的: 观察liguzinediol(2

5-二羟甲基-3

6-二甲基吡嗪)对戊巴比妥钠致急性心力衰竭大鼠血流动力学的影响。方法: 40只雄性SD大鼠右侧股静脉恒速注射戊巴比妥钠制备急性心衰模型

造模后随机分为5组:模型组(给予NS)

阳性对照组(地高辛

22.5 μg·kg-1)

liguzinediol(5

20 mg·kg-1)3个剂量组

每组8只

稳定后经恒速注射泵右侧股静脉单次给药

多道生理记录仪记录全过程中大鼠血流动力学指标的变化。结果: 静脉给药后

liguzinediol 3个剂量组均使大鼠左心室收缩压(LVSP)、左心室内压力最大上升速度(+dp/dtmax)、左心室内压力最大下降速度(-dp/dtmax)、收缩压(SAP)、舒张压(DAP)在1 min内开始显著增加

并且对心率影响不大

心肌收缩力增强。结论: liguzinediol 对急性心衰大鼠心脏具有正性肌力作用。

Abstract

Objective: To investigate the effect of liguzinediol on the hemodynamics in acute heart failure rats. Method: Forth rats were intravenously injected pentobarbital through a micro-infusion pump and randomly divided into 5 groups: saline control group (NS)

positive control group (digoxin

22.5 μg·kg-1)

three doses of liguzinediol groups (liguzinediol 5

20 mg·kg-1). The heart contractile founctions such as left ventricular systolic pressure (LVSP)

maximal rising and falling rate of ventricular pressure (±dp/dtmax)

systolic arterial pressure (SAP)

diastolic arterial pressure (DAP)

heart rate (HR) were measured using a RM6240B/C four channel physiological recording instrument. Result: Liguzinediol induced significant increases of LVSP

+dp/dtmax

-dp/dtmax

and SAP. Conclusion: Liguzinediol induces a positive inotropic effect on the heart in acute heart failure rats.

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