Influence of Sijunzi Decoction on Natural Killer Cell Activity and Serum TGF-and IFN-  in Rats with Chronic Fatigue Syndrome

LEI Bo; LIU Chang-zheng

您当前的位置：

首页 >

文章列表页 >

Influence of Sijunzi Decoction on Natural Killer Cell Activity and Serum TGF-and IFN- in Rats with Chronic Fatigue Syndrome

更新时间：2024-01-04

- Influence of Sijunzi Decoction on Natural Killer Cell Activity and Serum TGF-and IFN- in Rats with Chronic Fatigue Syndrome
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 12, Pages: 195-197(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
LEI Bo, LIU Chang-zheng. Influence of Sijunzi Decoction on Natural Killer Cell Activity and Serum TGF-and IFN- in Rats with Chronic Fatigue Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 195-197.
DOI：

LEI Bo, LIU Chang-zheng. Influence of Sijunzi Decoction on Natural Killer Cell Activity and Serum TGF-and IFN- in Rats with Chronic Fatigue Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 195-197. DOI：

摘要

目的: 探讨四君子汤对慢性疲劳综合征(chronic fatigue syndrome

CFS)模型大鼠自然杀伤(NK)细胞活性及血清转化生长因子-β(TGF-β)

γ干扰素(IFN- γ )水平的影响。方法: 选用SD大鼠为实验动物

共分为５组:模型组、空白组、治疗组(分低、中、高3个剂量组)

采取力竭游泳+剥夺睡眠20 h的复合造模方法造模

造模成功后给药组采用四君子汤ig

低、中、高剂量按生药量计分别为3.37

6.75

13.5 g·kg-1

空白组与模型组以蒸馏水ig

均每天1次

连续2周

2周后检测各组大鼠NK细胞活性及血清IFN- γ

TGF-β含量。结果: 模型组大鼠NK细胞活性及血清IFN-γ

TGF-β水平与正常大鼠比较

差异均具有高度统计学意义(P<0.01);而四君子汤组与模型组相比

低、中、高3个剂量组NK细胞活性及IFN-γγ含量均升高(P<0.05)

中、高剂量组TGF-β含量降低(P<0.05)。结论: 四君子汤能提高CFS模型大鼠NK细胞活性

升高血清IFN- γ 含量

降低TGF-β含量

具有改善CFS大鼠免疫功能的作用。

Abstract

Objective: To study the Influence of Sijunzi decoction on natural killer cell(NK) activity and serum interferon-γ(IFN- γ ) and transforming growth factor-β(TGF-β) in rats with chronic fatigue syndrome (CFS). Method: Animal model was prepared by exhaustion swimming and 20 hours' sleep deprivation.The SD rats were divided into 5 groups

model group

blank group and treatment group at low

mid and high dosage group (3.37

6.75

13.5 g·kg-1). After two weeks of treatment

NK activity and serum IFN- γ and TGF-β content were determined. Result: The NK activity and serum IFN- γ content was decreased

and TGF-β content was increased in model group

compared with blank group (P<0.01). The NK activity and serum IFN- γ content in treatment groups were higher and the TGF-β content was lower compared with model group (P<0.05); Conclusion: Sijunzi decoction could obviously enhance the NK activity and serum TGF-β content and reduce serum IFN- γ content

which could strengthen the immunity in rats with CFS.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect of Bushen Formulae on T Helper Cell 1, 17 and Regulatory T cell in Experimental Autoimmune Encephalomyelitis Mice

Effect of Jianpi Xiaoai Prescription on TGF-/lncRNA-ATB/miR-200a Signal Pathway in Colorectal Cancer

Preventive and Therapeutic Effect of Yangsheng Yishen Decoction on Early Staged Diabetic Nephropathy (DN) with Deficiency of Both Qi and Yin

Related Author

WANG Lei

ZHAO Hui

ZHENG Qi

KOU Shuang

WANG Yi-zhou

YIN Lin-lin

QI Fang

LI Ming

Related Institution

Shanxi University of Traditional Chinese Medicine,Department of Traditional Chinese Pharacology

Texas College of Traditional Chinese Medicine,Austin 04

Scetion of Sports Medicine,Sports Department,Shanghai University of Tractional Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰