Protective Effect of Guipi Tang on Acute Liver Injury Induced by Ethanol Extract from in Rats
|更新时间:2024-09-23
|
Protective Effect of Guipi Tang on Acute Liver Injury Induced by Ethanol Extract from in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 9, Pages: 169-171(2012)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2012
稿件说明:
移动端阅览
ZHOU Wen-jing, CHAI Zhi, WANG Yong-hui, et al. Protective Effect of Guipi Tang on Acute Liver Injury Induced by Ethanol Extract from in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 169-171.
DOI:
ZHOU Wen-jing, CHAI Zhi, WANG Yong-hui, et al. Protective Effect of Guipi Tang on Acute Liver Injury Induced by Ethanol Extract from in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 169-171.DOI:
Protective Effect of Guipi Tang on Acute Liver Injury Induced by Ethanol Extract from in Rats
Objective : To explore the protective effect and mechanism of Guipi Tang on acute liver injury reduce by ethanol extract from Tripterygium wilfordii in rats. Method : Totally 50 rats were randomly divided into control group
T. wilfordii model group
large-dose
medium-dose and small-dose groups of Guipi Tang(4.5
9
18 g·kg-1)groups. Each group was respectively perfused with the corresponding dose of drug for 5 days. Then T. wilfordii by Ethanol was perfused for 3 days to produce the mode 1. The pathological tissue of liver was detected. The serum levels of alanine aminotransferase(ALT)
aspartate aminotransferase(AST)
superoxide dismutase(SOD)
malondiadehyde(MDA) and glutathione peroxidase(GSH-Px) were measured. Result : Compared with the control group. The serum levels of SOD and GSH-Px in model group decreased and MDA increased obviously(P <0.05). Pathological investigation showed that liver cell steatosis was took place with cell turbid. Compared with model group
Guipi Tang of all doses could effectively decrease ALT
AST and MDA level
increase GSH-Px level(P <0.05). Large-dose and medium-dose also increased SOD level(P <0.05). The liver injury was alleviated. Conclusion : Guipi Tang has effect of protecting the liver and the mechanism of liver injury has a relationship with lipid peroxidation.