Acomparative Research on Quality of Huanglian Shangqing Tablets from Different Manufacturers

WANG Yin; SHEN Li; ZHOU Nong; LIU Shi-qingshui

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Acomparative Research on Quality of Huanglian Shangqing Tablets from Different Manufacturers

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- Acomparative Research on Quality of Huanglian Shangqing Tablets from Different Manufacturers
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 9, Pages: 99-103(2012)
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- Published：2012
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WANG Yin, SHEN Li, ZHOU Nong, et al. Acomparative Research on Quality of Huanglian Shangqing Tablets from Different Manufacturers[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 99-103.
DOI：

WANG Yin, SHEN Li, ZHOU Nong, et al. Acomparative Research on Quality of Huanglian Shangqing Tablets from Different Manufacturers[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 99-103. DOI：

摘要

目的: 研究不同厂家黄连上清片的质量情况以及对问题的分析

为提高药品标准

正确地评价药品质量提供理论依据。方法: 通过对7家生产厂家10批样品进行片芯质量测定

样品粉末显微镜观察

建立5种蒽醌类化合物(芦荟大黄素、大黄酸、大黄素、大黄酚和大黄素甲醚)含量测定方法

并对样品中5种蒽醌类化合物的含量进行测定并比较。结果: 不同生产厂家的产品显微观察无区别

但片重差异和5种蒽醌类化合物存在较大差异。结论: 不同厂家的黄连上清片由于制剂工艺、原材料质量等不同

导致了产品质量存在较大差异。

Abstract

Objective: To improve the drug standard and provide a theoretical basis for the correct evaluation of the quality of the drugs

the qualities of Huanglian Shangqing tablets from different manufactures were investigated and some problems were analyzed. Method: The core tablets of 10 batches from 7 manufacturers were weighed and the powder samples were microscopically observed. Method for determination of 5 kinds of anthraquinone (aloe-emodin

rhein

emodin

chrysophanol and physcion) was established and the content of anthraquinone was assayed. Result: There are no microscopic indifferences exist among different tablets

while the weight of the tablets as well as the content five kinds of anthraquinone was quite different. Conclusion: Big differences of the quality of the products exist among different products

which may result from different raw materials and preparation process.

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Related Author

WANG Yin1

SHEN Li2

ZHOU Nong1

LIU Shi-qingshui1

TANG Xian-hong

XIA Cong-long

ZHOU Nong

ZHONG Jia

Related Institution

College of Pharmacy,Dali University,Dali

Institute of Chinese Materia Medica,Chongqing Three Gorges Medical College

Department of Pharmacy,Dali University,Dali

Jilin Agricultural University

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

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