Content of Active Compounds in Water Extracts of Ephedra with Cinnamomi by Compatibility of Different Ratio

XU Wen-jie; CHEN Fei-long; XIE Ying; LUO Jia-bo

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Content of Active Compounds in Water Extracts of Ephedra with Cinnamomi by Compatibility of Different Ratio

更新时间：2024-01-04

- Content of Active Compounds in Water Extracts of Ephedra with Cinnamomi by Compatibility of Different Ratio
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 10, Pages: 84-88(2012)
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- Published：2012
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XU Wen-jie, CHEN Fei-long, XIE Ying, et al. Content of Active Compounds in Water Extracts of Ephedra with Cinnamomi by Compatibility of Different Ratio[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(10): 84-88.
DOI：

XU Wen-jie, CHEN Fei-long, XIE Ying, et al. Content of Active Compounds in Water Extracts of Ephedra with Cinnamomi by Compatibility of Different Ratio[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(10): 84-88. DOI：

摘要

目的: 研究麻黄-桂枝不同比例配伍前后水煎液中有效成分含量的变化

探讨两药的配伍规律。方法: 采用GC-MS测定水煎液中盐酸去甲基伪麻黄碱(NMP)、盐酸去甲基麻黄碱(NME)、盐酸麻黄碱(E)、盐酸伪麻黄碱(PE)、盐酸甲基麻黄碱(ME)的煎出量;采用HPLC测定水煎液中香豆素、桂皮醇和桂皮醛的煎出量。结果: 与单煎液相比

麻黄与桂枝配伍后

随着配伍药材比例增大

水煎液中以上各有效成分含量均有不同程度的降低

5种麻黄生物碱含量下降幅度在15%~42%

香豆素、桂皮醇、桂皮醛的含量下降幅度在16%~57%。结论: 麻黄-桂枝不同比例配伍后

对彼此有效成分的溶出有一定的抑制作用。

Abstract

Objective: Study on the content of active compounds in water extracts of Ephedra-Cinnamomi by compatibility of different ratio and to explain the mechanism of this compatibility. Method: The content of norpseudoephedrine (NMP)

norephedrine (NME)

ephedrine (E)

pseudoephedrine (PE) and methylephedrine (ME)

which are the major active compounds of Herba Ephedra

were analyzed by gas chromatography-mass spectrometry (GC-MS). The content of coumarin

cinnamic alcohol and cinnamaldehyde

which are the major active compounds of Cortex Cinnamomi in the extracts were analyzed by high performance liquid chromatography (HPLC). Result: The content of NMP

NME

coumarin

cinnamic alcohol and cinnamaldehyde in water extracts of pairmedicine Ephedra-Cinnamomi was lower than that of single decoction. Conclusion: Combined Ephedra with Cinnamomi

the dissolution of chemical compounds was inhibited with each other in water extracts.

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