Impact of Yinqin Qinggan Decoction on Serum NO, GSH-Px in Rats with Alcoholic Liver Disease

ZHANG Ya-xi; SHI Song; XIANG Ting-ting; YU Hui-jie; YE Zhi-hua

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Impact of Yinqin Qinggan Decoction on Serum NO, GSH-Px in Rats with Alcoholic Liver Disease

更新时间：2024-01-04

- Impact of Yinqin Qinggan Decoction on Serum NO, GSH-Px in Rats with Alcoholic Liver Disease
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 11, Pages: 181-184(2012)
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- Published：2012
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ZHANG Ya-xi, SHI Song, XIANG Ting-ting, et al. Impact of Yinqin Qinggan Decoction on Serum NO, GSH-Px in Rats with Alcoholic Liver Disease[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 181-184.
DOI：

ZHANG Ya-xi, SHI Song, XIANG Ting-ting, et al. Impact of Yinqin Qinggan Decoction on Serum NO, GSH-Px in Rats with Alcoholic Liver Disease[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 181-184. DOI：

摘要

目的: 研究茵芩清肝汤对酒精性肝病大鼠血清一氧化氮(NO)、谷胱甘肽过氧化物酶(GSH-Px)的影响。方法: 按每天8~12 mL·kg-1ig 52度白酒(随时间延长而递增

第1周为8 mL·kg-1

第2周10 mL·kg-1

第3周起12 mL·kg-1

以后继续维持此量

直至实验结束)配合高脂肪饲料喂养

造成大鼠酒精性肝病模型。随机分为模型组、正常组、茵芩清肝汤(20 g·kg-1 ig)组

硫普罗宁(5 mg·kg-1 ig)组、水飞蓟宾(5 mg·kg-1 ig)组进行比较。每组30只

分别于实验第4周、第8周、第12周每组各取大鼠10只

称重后以乙醚麻醉动物

迅速断头取血

按常规方法分离血清

测量NO

GSH-Px含量。结果: 模型组大鼠血清NO各阶段水平较正常组(15.36±7.2) μmol·L-1明显升高(P<0.01)

第12周达到(40.8±7.5)μmol·L-1(P<0.01)

GSH-Px各阶段水平较正常组(146.3±51.9) U·mg-1明显降低(P<0.01)

第12周达到(86.4±6.4)U·mg-1(P<0.01)。各治疗组大鼠血清NO各阶段水平较模型组均降低(P<0.05)

茵芩清肝汤组第12周达到(31.12±4.7)μmol·L-1(P<0.01);GSH-Px水平(107.7±31.1) U·mg-1较模型组均明显升高(P<0.01)。结论: 茵芩清肝汤可降低血清NO含量、提高GSH-Px活性

抑制脂质过氧化反应

这可能是它防治酒精性肝病的机制之一。

Abstract

Objective: To study the impact of Yinqin Qinggan decoction on serum nitric oxide(NO)

glutathione peroxidase(GSH-Px) in rats with alcoholic liver disease. Method: The rats were fed alcohol and high-fat diet to resultg in alcoholic liver model in rats. The rats were randomly divided into model group

control group

the Chinese medicines (Yinqin Qinggan decocotion)

west medicine group 1(tiopronin film)

west medicine group 2 (silibinin capsules)

with 30 eachgroup respectively.At 4 weeks

8 weeks and 12 weeks

respectively 10 rats in each group were executed to collect blood

sample and to measure NO

GSH-Px levels. Result: The serum levels of NO in the various stages of model group were significantly higher than the normal group (P<0.01). GSH-Px levels in the various stages was significantly lower than normal (P<0.01). Forth treatment groups in the various stages NO levels were lower than in model group (P<0.05); GSH-Px levels were significantly higher than in model group (P<0.01). Conclusion: Liver Yinqin Qinggan decoction can decrease serum NO levels

increase GSH-Px activity and inhibit of lipid peroxidation

which may be one of the mechanisms.

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