Influenction of Shuwei Decoction on Gastric Emptying, Serum Stem Cell Factors and Nitric Oxide in Functional Indigestion Raton
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Influenction of Shuwei Decoction on Gastric Emptying, Serum Stem Cell Factors and Nitric Oxide in Functional Indigestion Raton
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 3, Pages: 156-159(2012)
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Published:2012
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MI Yan-hong, GUO Xuan, WANG Xiao-juan, et al. Influenction of Shuwei Decoction on Gastric Emptying, Serum Stem Cell Factors and Nitric Oxide in Functional Indigestion Raton[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 156-159.
DOI:
MI Yan-hong, GUO Xuan, WANG Xiao-juan, et al. Influenction of Shuwei Decoction on Gastric Emptying, Serum Stem Cell Factors and Nitric Oxide in Functional Indigestion Raton[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 156-159.DOI:
Influenction of Shuwei Decoction on Gastric Emptying, Serum Stem Cell Factors and Nitric Oxide in Functional Indigestion Raton
Objective: To observe the influences and mechanism of Shuwei decoction on gastric emptying and the content of serum nitric oxide(NO)
stem cell factors(SCF) in functional dyspepsia(FD) rats. Method: The rats were randomly divided into control group
model group
Muxiang Shunqi pill group
mosapride group
Shuwei decoction high dose group
shuwei decoction low dose group
10 rats in each group. The model of FD was established by clasping their tails
4 times each day
lated 7 days. After 3 days
except control and model groups
the rats were given corresponding drugs for 14 days. The gastric emptying
the content of serum NO and SCF were observed. Result: Compared with control group
gastric emptying was delayed in the model group rats(P<0.05)
serum SCF level was decreased (P<0.05)
serum NO level was increased(P<0.05). Compared with model group corresponding drug groups (Muxiang Shunqi pill group
mosapride group
Shuwei decoction low dose group
Shuwei decoction high dose group) improved gastric emptying ; obviously increased on serum SCF(μmol ·L-1)
decreased on serum NO(μmol ·L-1)
and structure change of ICC in gastric antrum improved. Compared with Chinese patent medicine group and Shuwei decoction low dose group
the gastric emptying was improved (P<0.05)
serum NO was decreased (P<0.05). Conclusion: Shuwei decoction can recovery the function of gastrointestinal motility by regulating the level of serum NO
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Related Institution
Department of Gastroenterology,Hebei Provincial Hospital of Integrative Chinese and Western Medicine
Modern Research Center for TCM,Beijing Academy of TCM, Beijing University of Chinese Medicine
Dongzhimen Hospital, Beijing University of Chinese Medicine
Beijing Key Laboratory of Syndrome and Prescription Basic Research, Key Laboratory of Syndrome and Prescription Basic Research,Ministry of Education, School of Traditional Chinese Medicine(TCM),Beijing University of Chinese Medicine
Hebei Provincial Hospital of Traditional Chinese Medicine