Objective: To investigated the pathology effect of compound Qingqin on kidneys of rats with gouty nephropathy. Method: Male SD rats were randomly divided into 2 groups:normal group and model group. The model rats were induced by adenine. After the model was determined successfully

all model rats were divided into model group

allopurinol group

compound Qingqin 377 mg·kg-1group

Qingqin 188.50 mg·kg-1 group and Qingqin 94.25 mg·kg-1group

each consisting of 5 animals. Each group was given the corresponding drugs for 6 weeks. All rats were killed at 16 h after last dosing

then kidneys were taken out and fixed immediately with 10% formalin

embedded with paraffin

serially sectioned and stained with hematoxylin eosin (H.E) and periodic acid-sliver (PAS). To be classified and scored the renal lesions under the light microscope and the relative area of mesangium matrix was measared by under the PAS dyeing. Result: The renal tubular cells degeneration necrosis and uric-acid salts crystals lesions in the compound Qingqin 377 mg·kg-1 group was significantly lightened than the model group (P<0.05)

while its mesangium matrix relative area was no obvious difference from the model group. Conclusion :The compound Qingqin can significantly lighten the renal lesions of rats with gouty nephropathy after it is taken for 6 weeks by 377 mg·kg-1 and it has a protective effect to kidney.