Effects of Cordyceps Sinensis Mycelium Combined with Enalapril on Proteinuria in Patients with Early Diabetic Nephropathy

LI Hai-jian; LIU Hui; LI Yu-dong; TAO Ya-fei; REN Dong-sheng

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Effects of Cordyceps Sinensis Mycelium Combined with Enalapril on Proteinuria in Patients with Early Diabetic Nephropathy

更新时间：2024-01-04

- Effects of Cordyceps Sinensis Mycelium Combined with Enalapril on Proteinuria in Patients with Early Diabetic Nephropathy
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 11, Pages: 277-279(2012)
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- Published：2012
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LI Hai-jian, LIU Hui, LI Yu-dong, et al. Effects of Cordyceps Sinensis Mycelium Combined with Enalapril on Proteinuria in Patients with Early Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 277-279.
DOI：

LI Hai-jian, LIU Hui, LI Yu-dong, et al. Effects of Cordyceps Sinensis Mycelium Combined with Enalapril on Proteinuria in Patients with Early Diabetic Nephropathy[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 277-279. DOI：

摘要

目的: 观察虫草胶囊联合依那普利对早期糖尿病肾病患者尿蛋白排泄水平的影响。方法: 68例2型早期糖尿病肾病患者

随机分为对照组34例(依那普利)和治疗组34例(依那普利联合虫草胶囊)。疗程均为12周。观察UAER

24 h尿蛋白定量

尿α1-MG、尿β2-MG水平的变化。结果: 对照组治疗后UAER 、24 h尿蛋白定量、尿α1-MG、尿β2-MG分别为(167.4±19.2)mg·d-1

(89.1±15.0)mg

(19.1±8.1)mg·L-1

(331.5±36.5)μg·L-1

均较治疗前降低

差异有显著性(P< 0.05)

治疗组分别为(115.2±16.3)mg·d-1

(58.9±18.6)mg

(15.2±7.9)mg·L-1

(272.3±33.8)μg·L-1

也较治疗前降低

较对照组降低更明显

差异有显著性(P< 0.05)。两组治疗后HbA1c较治疗前略有下降

但差异无显著性。结论: 虫草胶囊联合依那普利能明显降低早期糖尿病肾病患者尿蛋白水平

使肾脏损伤程度减低

较单用依那普利作用明显。

Abstract

Objective: To observe the effects of cordyceps sinensis mycelium combined with enalapril on proteinuria in patients with early diabetic nephropathy. Method: Sixty-eight patients with early diabetic nephropathy were randomly divided into control group treated with enalapriland treatment grouptreated with enalapril and Ccordyceps Sinensis Mycelium

each group was treated for 12 weeks. The urinary albumin ejection rate(UAER)

24-hour urine protein

urine α1-microglobin(α1-MG)

β2-microglobin(β2-MG) and glycosylated hemoglobin(HbAlc) were measured before and after the treatment. Result: After treatment UAER

24-hour urine protein

α1-MG

β2-MG in both groups were significantly decreased compared with that before treatment(P<0.05)and the difference in combination group was significantly greater than that in single medication group(P<0.05).The difference of HbA1c before and after treatment had no statistical significance in both groups. Conclusion: The treatment with both cordyceps sinensis mycelium and enalapril can decrease proteinuria of Patients with early diabetic nephropathy markedly

and is better than the treatment with enalapril only.

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