Objective: To observe effect of the Aloe vera and its compound extract on inflammatory factors. Method: Cells diluted by 2×105/mL were inoculated into 96-well plates

100 μL per well

concentrations of druds was 250

125

62.5 g·L-1

MTT method was assay to test the toxic effects of macrophages. When the concentrations was 50

25

12.5 g·L-1 macrophage nitric oxide (NO) levels was measured. Enzyme-linked immunosorbent assay (ELISA) were used to measure tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) levels in pure drug and lipopolysaccharide (LPS)-induced murine macrophage. Result: Aloe vera and its compound extract promoted releasing of NO

with a concentration dependent manner (P<0.01); Aloe vera could promote TNF-α secretion (P<0.01) and inhibition of IL-10 secretion (P<0.05)

the compound inhibited LPS induced releasing of TNF-α and IL-10 (P<0.01). Conclusion: Aloe in 250-7.8 g·L-1 concentration has non-cytotoxic macrophages

compound extract has a certain toxic action

and can exert some influence on release of inflammatory factors.