Astragali Radix Influence on the Content Changes of Aristolochic Acid in Aristolochiae Fangchi and Tet in Stephania Tetrandra
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Astragali Radix Influence on the Content Changes of Aristolochic Acid in Aristolochiae Fangchi and Tet in Stephania Tetrandra
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 2, Pages: 111-114(2012)
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Published:2012
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LIANG Qi, ZHANG Yan-xia, XU Gang, et al. Astragali Radix Influence on the Content Changes of Aristolochic Acid in Aristolochiae Fangchi and Tet in Stephania Tetrandra[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 111-114.
DOI:
LIANG Qi, ZHANG Yan-xia, XU Gang, et al. Astragali Radix Influence on the Content Changes of Aristolochic Acid in Aristolochiae Fangchi and Tet in Stephania Tetrandra[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 111-114.DOI:
Astragali Radix Influence on the Content Changes of Aristolochic Acid in Aristolochiae Fangchi and Tet in Stephania Tetrandra
Objective: To study the chemical mechanism of Astragali Radix influence on Aristolochiae Fangchi and Stephania Tetrandra. Method: Aristolochic acid(AA) in aqueous extract of Aristolochiae Fangchi combined with Astragali radix and Tet in the aqueous extract of Stephania Tetrandra combined with Astragali Radix were determined by the method of HPLC. Result: The transfer rate of AA was 86.21% and 51.86% separately in aqueous extract of Aristolochiae fangchi and combined with Astragali Radix. The transfer rate of Tet was 56.45% and 63.03% separately in aqueous extract of Stephania Tetrandra and combined with Astragali Radix. Conclusion: The AA and Tet were all lose in the process of water extract. Matching that Astragali radix could decrease the dissolution rate of AA and increase the dissolution rat of Tet.
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Related Institution
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences
Key Laboratory of Basic and Applied Research of Northern Medicine, Key Laboratory of Basic Research on Pharmacodynamic Substances of Traditional Chinese Medicine and Natural Medicine in Heilongjiang Province, Heilongjiang University of Chinese Medicine
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