The Study on Promotion of Absorption and Synergistic Effect of Chuanxiong Rhizoma with Helicid
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The Study on Promotion of Absorption and Synergistic Effect of Chuanxiong Rhizoma with Helicid
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 1, Pages: 176-178(2012)
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Published:2012
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SU Zhe-tong, XU Jia-li, LIU Ying, et al. The Study on Promotion of Absorption and Synergistic Effect of Chuanxiong Rhizoma with Helicid[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 176-178.
DOI:
SU Zhe-tong, XU Jia-li, LIU Ying, et al. The Study on Promotion of Absorption and Synergistic Effect of Chuanxiong Rhizoma with Helicid[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 176-178.DOI:
The Study on Promotion of Absorption and Synergistic Effect of Chuanxiong Rhizoma with Helicid
Objective: To study synergistic effect of Chuanxiong Rhizoma with helicid. Method: Using in vitro absorption model of rat
effects of Chuanxiong Rhizoma on absorption of helicid were observed and accumulation absorptive amount (Q) was calculated. Rat migraine model was induced by nitroglycerin
level of 5-HT and CGRP were measued. Result: Q value of helicid with rhizoma chuanxiong was enhanced from 53.72 μg to 335.48 μg
increased pharmacodynamic action(P<0.05). Conclusion: Chuanxiong Rhizoma not only promote absorption of helicid
but increase pharmacodynamic action.Thus
the research result demonstrates the function of 'unification of drug and adjuvant’.
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