Protective Effect of Shenzhi Shuxue Drop Pills on Focal Cerebral Ischemia in Rats
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Protective Effect of Shenzhi Shuxue Drop Pills on Focal Cerebral Ischemia in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 1, Pages: 173-175(2012)
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Published:2012
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ZHANG Xiao-shuang, ZHAO Lin-tao, SONG Yan-ping, et al. Protective Effect of Shenzhi Shuxue Drop Pills on Focal Cerebral Ischemia in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 173-175.
DOI:
ZHANG Xiao-shuang, ZHAO Lin-tao, SONG Yan-ping, et al. Protective Effect of Shenzhi Shuxue Drop Pills on Focal Cerebral Ischemia in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 173-175.DOI:
Protective Effect of Shenzhi Shuxue Drop Pills on Focal Cerebral Ischemia in Rats
Objective: To study the influence of Shenzhi Shuxue drop pills on focal cerebral ischemia model in rats. Method :The local cerebral ischemia in rat was made by middle cerebral artery occlusion
Successful model 48 rats were randomly divided into sham operation group
model control group
positive group (Xuesaitong tablets 0.04 g ·kg-1)and Shenzhi Shuxue drop pills high
medium and low dose group (0.936
0.468
0.234 g ·kg-1)
in each group 8 rats.Rats were given above medicines of 10 mL ·kg-1intragastrically once a day for 14 days. Neurological score
infarct size ratio and superoxide dismutase (SOD) activity
malondialdehyde (MDA) content in inserum were observed. Result: Shenzhi Shuxue drop pills high
medium dose group and positive group could decrease neural behavioral score
reduce infarct area ratio
increase the activity of SOD content in serum(P<0.05
P<0.01).Shenzhi Shuxue drop pills high
medium and low dose group and positive group could decrease MDA content in serum(P<0.05
P<0.01). Conclusion: Shenzhi Shuxue drop pills has protective effect on focal cerebral ischemia in rats
and its mechanism may be related toscavenging of free radical.
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