Effect of Shexiang Wulong Wan on the Pathomorphology and Expresssion of TNF- and IL-6 in Synovium in the Rats with Adjuvant Arthritis
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Effect of Shexiang Wulong Wan on the Pathomorphology and Expresssion of TNF- and IL-6 in Synovium in the Rats with Adjuvant Arthritis
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 6, Pages: 234-236(2012)
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Published:2012
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CHEN Shou-zhong, YUAN Qiang, ZHANG Ai-guo, et al. Effect of Shexiang Wulong Wan on the Pathomorphology and Expresssion of TNF- and IL-6 in Synovium in the Rats with Adjuvant Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 234-236.
DOI:
CHEN Shou-zhong, YUAN Qiang, ZHANG Ai-guo, et al. Effect of Shexiang Wulong Wan on the Pathomorphology and Expresssion of TNF- and IL-6 in Synovium in the Rats with Adjuvant Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 234-236.DOI:
Effect of Shexiang Wulong Wan on the Pathomorphology and Expresssion of TNF- and IL-6 in Synovium in the Rats with Adjuvant Arthritis
Objective: To observe the effects of Shexiang Wulong Wan(SXWLW) on the pathomorphology and tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in synovium rats with adjuvant arthritis. Method: Adjuvant arthritis (AA)animal model was reproduced.Forty Wistar male rats were divided randomly into 4 groups.model group
normal group treated with normal saline (NS)of 2 mL every day; SXWLW low dose group treated with 1.0 g·kg-1 every day; SXWLW high dose group treated with 2.0 g·kg-1 every day. At the end of the experiment
toe metatarsal joints were collected for pathological examination.The level of TNF-α and IL-6 was checked by immunohistochemical methed. Result: SXWLW low dose and high dose groups
compared with the model group
synovial tissue of damage was significantly reduced; the expression of TNF-α and IL-6 in the SXWLW low dose group and high dose group
compared with model group
decreased (P<0.01 or P<0.05). Conclusion: SXWLW can reduce the expression of TNF-α and IL-6 in the synovial tissue
therefore it could decrease synovial tissue damage.