Objective:To study on purification technology conditions of total flavonoids from Carthamus tinctorius by macroporous resin. Method: Absorption rate and desorption rate of total flavonoids were taken as indexes

investigated absorption and desorption ability of 6 different types macroporous resin to safflower flavonoids

determined AB-8 was optimum macroporous resin.Purification conditions of AB-8 macroporous resin were optimized. Result:Optimum technology conditions were as follows:liquid concentration was 50 g ·L-1 (pH 2)

flow rate of sample was 4 BV ·h-1; eluted with 3 BV the amount of 30% ethanol by speed of 2 BV ·h-1.After purified with AB-8 macroporons resin

purity of total flavonoids was up to 54.04%

purity of hydroxysafflor yellow A was up to 28.76%

separation effect was good. Conclusion: AB-8 resin was fit for separating and purifying of total flavonoids from safflower.