The Effect of Taohong Siwu Granule on Acute Myocardial Ischemia injury Induced by Pituitrin in Rats
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The Effect of Taohong Siwu Granule on Acute Myocardial Ischemia injury Induced by Pituitrin in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 5, Pages: 197-200(2012)
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Published:2012
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CHEN Yu-xing, DU Tie-liang, HUANG Xue-jun, et al. The Effect of Taohong Siwu Granule on Acute Myocardial Ischemia injury Induced by Pituitrin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(5): 197-200.
DOI:
CHEN Yu-xing, DU Tie-liang, HUANG Xue-jun, et al. The Effect of Taohong Siwu Granule on Acute Myocardial Ischemia injury Induced by Pituitrin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(5): 197-200.DOI:
The Effect of Taohong Siwu Granule on Acute Myocardial Ischemia injury Induced by Pituitrin in Rats
Objective: To observe the effect of Taohong Siwu granule(THSWG)on with acute myocardial ischemia injury induced by pituitrin(Pit) in rats. Method: The 70 rats were divided into normal control group
model control group
amiodarone 0.094 5 g·kg-1 group
CSDP 2.7 pills·kg-1 group
THSWG 18.36
9.18
4.59 g·kg-1 group. The rat acute myocardial ischemia injury was induced by femoral vein perfusion with Pit
and the percentage changes of the T wave and the heart rate were observed after 30
60
90 min of administration. And other rat acute myocardium ischemia models were established by sublingual venous injection of Pit
the levels of the serum creatine phosphokinase(CK) and the lactate dehydrogenase (LDH) of the rats were examined after taking THSWG for 5 days. Result: Compared with the model control group
the percentage changes of the T wave and the heart rate were significantly reduced(P<0.01)
the levels of the serum CK and LDH of the rat models were also significantly decreased(P<0.01) after taking THSWG. Conclusion: THSWG could protect the rats against acute myocardial ischemia induced by Pit.